Advances in the diagnosis and management of toxic megacolon (Part 5)

However, the blowhole decompression procedure is performed only rarely and the reported experience with this procedure is, therefore, limited to a few centres. Looking to the future, the authors noted that NO levels are increased in cases of TM, and this may represent a key pathway driving the toxic dilation. Recent work suggests that the suppression of NO production may be the reason why corticosteroids are effective in IBD-related cases of TM . Early use of corticosteroids may prevent the progressive cascade of inflammation and dilation. Future therapies involving suppression of inducible NO are in the experimental stages. If you want to make your online shopping advantageous and safe, check out the best pharmacy to buy antibiotics levaquin only here without any need for a prescription, any time of the day or night with straight to the doorstep delivery.

Gan and Beck provide physicians with an insightful and comprehensive review of TM, highlighting the strengths and weaknesses of current treatment regimes while acknowledging the paucity of good prospective data. Gastroenterologists and surgeons are reminded of the complex clinical presentation and course of this disease, and the importance of an aggressive medical treatment strategy with consideration of early surgical intervention.

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