Archive for the ‘Allergic’ Category

Sinobronchial Allergic Mycosis: Conclusion

The relationship between CFTR gene mutations and AFS is unknown. The possibility that CFTR gene mutations also may contribute to the development of AFS or put patients with either ABPM or AFS at risk for the development of the SAM syndrome requires further study. An epidemiologic survey found that persons heterozygous for the AF508 mutations […]

Sinobronchial Allergic Mycosis: CFTR

Mast cell-derived products released in such IgE-mediated reactions include histamine, a mucus secretagogue. Variations in the viscosity of the mucus produced or the induction of nasal polyposis, also contributing to airways obstruction, also could play a role in the process canadian pharmacy levitra. There is no evidence to suggest that AFS or ABPM results from […]

Sinobronchial Allergic Mycosis: Eosinophil-derived

Other data also suggest that the pathogenesis of these diseases is similar. In a review of the histopathologic features of AFS, Kahn et al noted the histopathologic similarities between ABPM and AFS. There is evidence for the active contribution of both eosinophil-derived and neutrophil-derived products, including eosinophil major basic protein and neutrophil elastase, like that […]

Sinobronchial Allergic Mycosis: Discussion

Four other patients met the diagnostic criteria and were included with our patient to form the five case reports used in our analysis. The patients were 17 to 55 years of age, and the group included three men and two women. Presenting complaints varied from purulent nasal discharge and obstruction to chest discomfort with cough […]

Sinobronchial Allergic Mycosis: Results

Stringent diagnostic criteria for ABPM and AFS were used for inclusion of case reports in this study. Diagnostic criteria for AFS, as previously published by us, include the following: (1) radiologic evidence of sinusitis of one or more paranasal sinuses; (2) histopathologic identification of fungal elements in eosinophil-rich allergic mucin; (3) the absence of invasive […]

Sinobronchial Allergic Mycosis: Materials and Methods

One copy of the D1270N mutation in the CFTR gene was detected. Sweat chloride concentrations, as determined by quantitative pilocarpine iontophoresis on each arm, were 19 and 24 mEq/L, with a normal range of < 40 mEq/L. Postoperatively, the patient was treated with 0.5 mg/kg prednisone daily for 1 month plus topical nasal steroids by […]

Sinobronchial Allergic Mycosis: Allergy

Investigation of frozen sections showed bronchiolar mucous impaction, allergic mucin, and rare hyphae with no evidence of tissue invasion. Functional endoscopic sinus surgery was performed with a right-sided polypectomy, anterior and posterior ethmoidectomy, maxillary antrostomy, and frontal recess dissection. Large quantities of polypoid material with a peanut butter consistency were removed from the sinuses further […]

Sinobronchial Allergic Mycosis: Case Report

A 17-year-old, African-American, male, high school athlete with mild intermittent asthma presented to the University of Mississippi Medical Center for the evaluation of chronic sinusitis. A physical examination demonstrated an edematous nasal mucosa, nasal polyps, and thick mucus. Bilateral wheezes were present on auscultation of the chest. Despite long-term antibiotic therapy and therapy with topical […]

Sinobronchial Allergic Mycosis

Allergic fungal sinusitis (AFS) is a noninvasive form of fungal sinusitis that is seen in highly atopic individuals with fungal-specific IgE, intractable sinusitis, and nasal polyposis. Chronic bacterial sinusitis results when large accumulations of eosinophil-rich allergic mucin containing sparse fungal elements cause mucous impaction and obstruction of the osteomeatal complex. Mucous plugs may become an […]