Archive for the ‘Apnea’ Category

The Effect of Successful Heart Transplant Treatment of Heart Failure on Central Sleep Apnea: Summary

A third of patients with CSA before transplant acquired OSA after transplant. This alteration in apnea type cannot be explained by variations in body weight or dosage of prednisolone between the three patient groups after transplant, nor could we identify upper airway anatomic differences. No patient in the control group acquired OSA despite a similar […]

The Effect of Successful Heart Transplant Treatment of Heart Failure on Central Sleep Apnea: Discussion

This study demonstrated two unique observations: first, CHF patients with CSA who undergo heart transplantation may have persistent CSA beyond the peritransplant period (> 6 months) despite normalization of heart function and sympathetic activity. Second, CSA severity is attenuated and the cycle length plus ventilation:apnea ratio are altered in appearance, similar to that seen with […]

The Effect of Successful Heart Transplant Treatment of Heart Failure on Central Sleep Apnea: CSA

Of the 13 patients with CSA before transplant, 3 patients had persistent CSA, 4 patients had OSA, and 6 patients had no SDB (AHI, 36.1 ± 10.0 to 12.3 ± 0.9/h, 18.0 ± 4.2 to 11.2 ± 7.4/h, and 31.4 ± 6.5 to 1.3 ± 0.9/h, respectively) on follow-up sleep studies. The characteristics of the […]

The Effect of Successful Heart Transplant Treatment of Heart Failure on Central Sleep Apnea: Results

Between the years of 1999 and 2000, 37 patients with severe CHF underwent heart transplantation workup that included full polysomnography who subsequently received a heart transplant: 16 patients had CSA, 6 patients had OSA, and 15 patients had no SDB (control group). In the CSA group following heart transplantation, one patient was excluded due to […]

The Effect of Successful Heart Transplant Treatment of Heart Failure on Central Sleep Apnea: UNE

Sleep was manually staged according to standard criteria. A central apnea was defined as absence of oronasal airflow during sleep for > 10 s associated with absent respiratory effort. A central hypopnea was defined as any reduction in oronasal airflow for > 10 s associated with in phase thoracoabdominal movement and > 2% fall in […]

The Effect of Successful Heart Transplant Treatment of Heart Failure on Central Sleep Apnea: Materials and Methods

Subjects and Protocol Patients with a diagnosis of ischemic or idiopathic cardiomyopathy, and selected for heart transplantation assessment were included in the study. Patients with congenital, valvular, or restrictive heart disease were excluded. All patients were optimally treated and considered medically stable at the time of heart transplantation assessment. At the time of heart transplantation […]

The Effect of Successful Heart Transplant Treatment of Heart Failure on Central Sleep Apnea

Central sleep apnea (CSA) associated with Cheyne-Stokes respiration is observed during stages 1 and 2 sleep in approximately 30% of patients with congestive heart failure (CHF), and is characterized by typical waxing and waning hyperventilation interspersed with central apneas or hypopneas. It has been shown that hyperventilation results from acquired changes in ventilatory responses to […]

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