Category: ARDS

The Changing Face of Organ Failure in ARDS: Conclusion

APACHE II scores between the 1984-to-1990 and 1994-to-1999 patient groups were equivalent, so it is unlikely that group severity of illness was substantially different. The risk factors for the development of ARDS were not statistically different between the groups, but there was a nonstatistically greater percentage of pneumonia and sepsis (without significant changes in the contribution from trauma) in the earlier ARDS group. We recognize…

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The Changing Face of Organ Failure in ARDS: Discussion


Fewer total nonpulmonary organ failures were noted in 1994-to-1999 patients (Fig 3, with more patients having no and one organ failure, and fewer patients having two and three organ failures in 1994 to 1999 (p < 0.05). Cardiovascular and CNS failure, and sepsis were significantly lower prior to ARDS onset (Fig 4) and after ARDS onset (Fig 5) among 1994-to-1999 patients. Hepatic failure was lower…

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The Changing Face of Organ Failure in ARDS: ARDS onset


All data for scoring were collected prospectively and daily for all time points, and were stored in the database. APACHE (acute physiology and chronic health evaluation) II score was calculated prospectively, using the data from the first 24 h after the onset of ARDS. We used the lowest recorded Glasgow coma scale prior to intubation and/or after the patient was extubated to determine CNS failure….

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The Changing Face of Organ Failure in ARDS: ARDS identification

From February 1994 to March 1996, we identified ARDS patients by the presence of all of the following: (1) acute onset of lung injury requiring endotracheal intubation and mechanical ventilation; (2) Pao2/fraction of inspired oxygen (Fio2) ratio (P/F) £ 150 mm Hg; (2) Pw of £ 18 mm Hg or no clinical evidence of left atrial hypertension; (3) diffuse chest radiograph infiltrates in three of…

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The Changing Face of Organ Failure in ARDS

Reported mortality in ARDS patients varies from 30 to 50%. These values are lower than those previously reported. Zilberberg and Epstein2 reported that the lower mortality in ARDS was independent of the initial level of arterial oxygenation. The North American-European Consensus Conference redefined the criteria for ARDS. These new criteria require less severe arterial hypoxemia and may identify less severely injured patients than did previous…

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