Archive for the ‘Asthma’ Category

Alterations in Airway Inflammation and Lung Function During Corticosteroid Therapy for Atopic Asthma:

The search for associations between changes in measures of airway inflammation and physiology is made complex by the variability of measures over time, because variability is the hallmark of asthma. The current data suggest that changes in airway inflammation and lung function are closely related, but associations between changes in these two processes may be […]

Alterations in Airway Inflammation and Lung Function During Corticosteroid Therapy for Atopic Asthma: Discussion

Correlations Between Changes in Lung Function and Airway Inflammation With regard to associations between changes in airway inflammation and changes in lung function, changes in EG1 were associated with changes in bronchodilator response (r = 0.77, p = 0.016) only after a period of 8 weeks (Fig 4). There was no association between the rates […]

Alterations in Airway Inflammation and Lung Function During Corticosteroid Therapy for Atopic Asthma: Statistics

The intraindividual ratios of change after 2 weeks of therapy (measure at 2 weeks divided by measure at baseline) and 8 weeks of therapy (measure at 8 weeks divided by measure at baseline) were calculated for each parameter. Spearman correlation coefficients between ratios of change at both time intervals were calculated using SAS software (SAS […]

Alterations in Airway Inflammation and Lung Function During Corticosteroid Therapy for Atopic Asthma: Immunohistology

Cryostat sections (6 |j,m in thickness) of the endobronchial biopsy samples were cut at — 25°C and placed onto poly-L-lysine-coated microscope slides. The slides were air dried for 60 min, fixed in chloroform/acetone (1:1), wrapped in cling film, and stored at — 20°C until used. Each biopsy sample was sectioned within 1 month of freezing. […]

Alterations in Airway Inflammation and Lung Function During Corticosteroid Therapy for Atopic Asthma: Fiberoptic Bronchoscopy

Bronchodilator medication and caffeine-containing drinks were withheld for at least 12 h before each study visit, and subjects always attended the laboratory at 9 am. Compliance with medication and adverse effects were checked and recorded during each visit. One day prior to each fiberoptic bronchoscopy (day 0-1, day 13, and day 55), histamine bronchial provocation […]

Alterations in Airway Inflammation and Lung Function During Corticosteroid Therapy for Atopic Asthma: Study Design

Nine subjects with atopic asthma (five male subjects; mean age, 29 years; American Thoracic Society diagnostic criteria for asthma) received inhaled FP, 2,000 ^g/d for 8 weeks. Baseline characteristics are presented in Table 1. No subjects had an exacerbation of asthma or had received corticosteroid therapy within the 3 months prior to the study. Baseline FEV1 […]

Alterations in Airway Inflammation and Lung Function During Corticosteroid Therapy for Atopic Asthma: Materials and Methods

The use of endobronchial biopsy is considered a “gold standard” technique for the quantification of airway inflammation, When numbers of T cells, macrophages, and eosinophils are quantified by immunohistochemistry and computerized image analysis, the measures are highly reproducible at the within-section, within-biopsy, and intraindividual levels. We have previously shown that interindividual variability is greater than […]

Alterations in Airway Inflammation and Lung Function During Corticosteroid Therapy for Atopic Asthma

Corticosteroids are the most effective therapy for asthma, and current guidelines emphasize their use in all but mild asthma. Corticosteroid therapy down-regulates airway inflammation and improves lung function. Some studies suggest that steroid-induced changes in bronchial inflammation and lung function are closely associated. Other data suggest that changes in these two processes occur independently. Heterogeneity […]

Reduction of Eosinophilic Inflammation in the Airways: Conclusion

Prompt improvement of bronchoconstriction by CysLT1-receptor antagonists has been reported in asthma. In fact, bronchodilatory effect was observed several hours after treatment with CysLT1-receptor antagonists. In the present study, we found that treatment with montelukast resulted in significant increases in both morning and evening PEF compared with the baseline values. Because the number of patients […]

Reduction of Eosinophilic Inflammation in the Airways: Discussion

The effects of montelukast on airway eosinophilic inflammation have been reported previously. Although a significant decrease in sputum eosinophils was demonstrated in the previous study, baseline percentages of sputum eosinophils were significantly higher in the placebo group than in the montelukast group. In the present study, none of the baseline parameters, including the percentage of […]

Pages: 1 2 Next
anosiahuman.com