Archive for the ‘Cardiac Dysfunction’ Category

Subclinical Cardiac Dysfunction in Sarcoidosis (17)

Furthermore, in contrast with the results seen in the sarcoid population, the SHR during exercise would be expected to be normal if poor effort accounted for their low maximum Vo2. Another potentially confounding variable in the interpretation of our results is the possible effect of corticosteroid medications on cardiovascular and peripheral muscle function. However, no […]

Subclinical Cardiac Dysfunction in Sarcoidosis (16)

However, in contrast with the sarcoid patients, the AT in detrained subjects is generally found to be above 40 percent of maximum predicted Vo2. The control subjects in our study were purposely chosen to be sedentary (ie, not participating in regular exercise programs), and some detraining was expected. However, the AT and SHR were different […]

Subclinical Cardiac Dysfunction in Sarcoidosis (15)

These results suggest that the reasons for the abnormal cardiac response during exercise are not simple and more than one explanation should be sought. Regardless of the cause, however, it seems likely that impaired cardiac function is a limiting factor to exercise in patients with sarcoidosis.

Subclinical Cardiac Dysfunction in Sarcoidosis (14)

The group with fast HR responses and normal resting ejection fraction could be explained in two ways: the normal ejection fraction at rest may fail to increase appropriately or may even decrease during exercise, or these patients may have chronotropic abnormalities secondary to sarcoidotic involvement in and around the sinus node. In favor of the […]

Subclinical Cardiac Dysfunction in Sarcoidosis (13)

We further investigated the possible mechanism of the chronotropic abnormalities found in the patients with sarcoidosis by performing RNA to determine if the abnormal HRs were a result of impaired ventricular contractility. Systolic dysfunction, as demonstrated by low LVEF (<50 percent), was seen in 10 of 28 subjects with sarcoidosis and in only one of […]

Subclinical Cardiac Dysfunction in Sarcoidosis (12)

Cardiac abnormalities were frequently present at rest and during exercise in the subjects with sarcoidosis. Twenty percent had abnormal resting ECGs showing sinus tachycardia, sinus bradycardia, or normal sinus rhythm with right bundle branch block. Furthermore, continuous ambulatory ECG monitoring showed that the patients with sarcoidosis had significantly higher HRs during normal daily activities than […]

Subclinical Cardiac Dysfunction in Sarcoidosis (11)

Discussion This study shows that patients with sarcoidosis frequently have symptomatic limitations to exercise accompanied by abnormal circulatory responses, suggesting that subclinical cardiac involvement in sarcoidosis is a common occurrence that is evident during exercise. buy cipro

Subclinical Cardiac Dysfunction in Sarcoidosis (10)

Radionuclide Equilibrium Angiography Twenty-eight patients with sarcoidosis and 18 normal control subjects were studied with RNA (Table 2). There were no significant differences in age, FEVi, and vital capacity between the 28 patients and 18 controls. Resting LVEF was significantly lower in the patients with sarcoidosis compared with controls (53.1 ± 4.2 percent vs 63.1 […]

Subclinical Cardiac Dysfunction in Sarcoidosis (9)

Although the slope of the minute ventilation response to exercise (Table 2) was significantly greater in the group with sarcoidosis than normal controls (p<0.001), none of the patients reached predicted maximum voluntary ventilation (MW). Maximum Ve was not significantly different between the groups (Table 2). Three patients exceeded 80 percent of Ve/MW (Table 2). Arterial […]

Subclinical Cardiac Dysfunction in Sarcoidosis (8)

Six-hour group mean HR values and hourly ectopic beat rates for the 17 patients with sarcoidosis and 12 normal controls obtained by Holter monitoring are shown in Table 2. Mean HR was significantly higher in the group with sarcoidosis compared with control subjects for each of the three periods studied. Activity level was comparable between […]

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