Archive for the ‘Estradiol’ Category

Diethylstilbestrol Versus Estradiol: DISCUSSION(7)

That is, it neither inhibits nor enhances the change in size or histology (epithelial cornification) of the cervix, but it results in progressive histopathological responses in the uterus. Why neonatal DES exposure permanently alters estrogen responsiveness in the uterus, but not in the cervix, of adult hamsters is not yet known. A related question is […]

Diethylstilbestrol Versus Estradiol: DISCUSSION(6)

The uteri and cervices of the prenatally DES-exposed mice exhibited the same hypertrophic/hyperplastic/hyperestrogenic qualities that we observed in the neonatally DES-exposed hamsters, whereas those of the neonatally DES-exposed mice were hypotrophic. Thus, we conclude that 1) in addition to the differential effects observed in the prepubertal cervix, neonatal DES, but not E2, treatment induces long-term […]

Diethylstilbestrol Versus Estradiol: DISCUSSION(5)

In mature animals with ovaries, neonatal DES, but not E2, treatment resulted in hypertrophic cervical regions and a squamous epithelium in the ectocervix that was extensively cornified. In guinea pigs at a similar stage of maturity, DES, but not E2, treatment also resulted in hypertrophy of the cervical region, but cornification of the luminal epithelium […]

Diethylstilbestrol Versus Estradiol: DISCUSSION(4)

Other precocious events occur in the prepubertal hamster uterus following neonatal DES, but not E2, treatment. One such event, reported previously and confirmed in the present study, is the development of pseudostratification in the columnar epithelium of the endometrial lumen. Another is the development of invaginating endometrial glands. More recently, we also detected precocious induction […]

Diethylstilbestrol Versus Estradiol: DISCUSSION(3)

On the other hand, a recent report that focused on a variety of putative ED agents raises the possibility that potency as a perinatal ED agent at the whole animal level may rely on characteristics other than a given agent’s relative estrogenicity as assessed by simple in vitro assays of binding affinity to the estrogen-receptor (ER) […]

Diethylstilbestrol Versus Estradiol: DISCUSSION(2)

Because AFP in most rodents is an effective binder of E2 but not of DES, reduced bioavailability of perinatally administered E2 would seem to be a reasonable explanation for its lower potency as a perinatal ED agent compared to DES. However, that cannot be the case for the differential ED potency of E2 versus DES […]

Diethylstilbestrol Versus Estradiol: DISCUSSION(1)

The tissue archive used for the present study documents the disruption phenomenon that develops throughout the female reproductive tract of hamsters following neonatal exposure to either DES or E2. It includes both the prepubertal and mature stages in intact animals plus what happens in mature animals after they are ovariectomized prepubertally and then chronically stimulated […]

Diethylstilbestrol Versus Estradiol: RESULTS(6)

These changes in absolute size of the cervix induced by neonatal treatment were not statistically significant (Fig. 9B), but they did follow the same pattern as that noted above for body weight. Consequently, normalized cervical size (Fig. 9C) was not affected by either neonatal treatment regimen in the O+E2 hamsters. Figure 9 also shows that, […]

Diethylstilbestrol Versus Estradiol: RESULTS(5)

Specifically, the luminal epithelium in the lower uterine region adjacent to the cervix (Fig. 8, right) was 1) low cuboidal in control animals, 2) slightly taller and pseudostratified in E2-treated animals, and 3) extremely tall in neonatally DES-exposed animals. In addition, the cell’s basal aspects were difficult to distinguish from the underlying stromal tissue compartment […]

Diethylstilbestrol Versus Estradiol: RESULTS(4)

The differential effect of neonatal DES vs. E2 treatment on cervical size was modest and somewhat variable (Fig. 6, A and B), but the differential effect of the two treatments on histomorphology of the adult cervix was striking and very consistent from the 2-mo time point onward. For instance, the low-magnification micrographs in Figure 7 […]

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