Archive for the ‘Lung’ Category - Part 3

Methacholine-Induced Temporal Changes in Airway Geometry and Lung Density by CT: Lung Density Measurements

To look for potential radial regional differences in the lung, a similar analysis was performed separating the selected ROIs into peripheral and central locations. Peripheral ROIs were located within 5 to 7 mm of the lung border, while the rest of the lung field was defined as central.  Because of concern that using the sharp […]

Methacholine-Induced Temporal Changes in Airway Geometry and Lung Density by CT: EBCT

This study utilized the FASTRAC C-100 CT scanner (Imatron; South San Francisco, CA), an electron-beam scanner, employing the “high-resolution” mode. The following parameters were used: 512 X 512 matrix, 12.7-cm reconstruction circle (in plane pixel dimension = 0.248 mm), 3 mm-slice thickness, 2-mm-slice increments, 125 kilovoltage peak and 310 mA, and 200-ms scan times. Multiple […]

Methacholine-Induced Temporal Changes in Airway Geometry and Lung Density by CT

Recent advances in the use of high-resolution CT (HRCT) techniques have led to improved tools for the assessment of lung structure and function related to a number of clinically relevant questions, including airway reactivity. We have previously demonstrated the feasibility of electron-beam CT (EBCT) to objectively measure dose-related changes in airway geometry during IV methacholine-induced […]

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