Archive for the ‘Menopause’ Category

Nonhuman Primate Models of Menopause (Part 24)

Third, seasonal menstrual cycles in rhesus monkeys may confound reproductive aging studies. Seasonality should be considered when interpreting studies of reproductive aging and the pathophysiology of menopause-related health problems and conditions. Fourth, many of the studies exploring health and cognitive changes associated with surgical menopause, and the effects of estrogen on these changes, utilized young […]

Nonhuman Primate Models of Menopause (Part 23)

Research Approaches to Explore Apparent Differences Between NHP and Human Menopause/Aging Important differences between NHP and human females must be considered. First, the length of the postmenopausal life span is considerably shorter in NHPs, probably not more than 6-7 yr in rhesus monkeys and baboons and less than 1 yr in chimpanzees, and relative to […]

Nonhuman Primate Models of Menopause (Part 22)

Whether cognitive decline occurs concomitant with reproductive decline and/or aging is unclear. Limited data gathered from studies of surgically or naturally menopausal NHPs suggest that estrogen states can modulate cognitive function in both young and old monkeys. However, the specific cognitive processes that may be influenced by estrogen may depend on age, with multiple domains […]

Nonhuman Primate Models of Menopause (Part 21)

Additional similarities are seen in nonreproductive measures between aging human and NHP females. These include age-related changes in metabolic parameters of rhesus monkeys and baboons that are similar to those in humans, such as gains in weight and increases in relative body fat content, with tendencies toward abnormal glucose tolerance and increased insulin resistance, up […]

Nonhuman Primate Models of Menopause (Part 20)

The NHP Models of Menopause Workshop was convened to review the current status of knowledge regarding the suitability of the NHP as a valid model of the human menopausal process, including the etiology of postmenopausal health problems and conditions. To what extent do parallelisms exist in the NHP and human female reproductive aging process that […]

Nonhuman Primate Models of Menopause (Part 19)

Another study showed that learning and performance of the spatial memory task, delayed response, was impaired in irregularly cycling or postmenopausal, middle-aged rhesus monkeys compared to middle-aged or young monkeys with regular menstrual cycles. Similarly, in a small study using surgically menopausal middle-aged (age, 22 yr) rhesus monkeys, both delayed response performance and visuospatial attention […]

Nonhuman Primate Models of Menopause (Part 18)

Cognitive Changes During Menopause This discussion of cognitive changes during menopause is based on the presentation by Dr. Mary Lou Voytko (Wake Forest University School of Medicine). Results from studies in women regarding the role of menopause in altering cognitive function relative to all other factors associated with middle age are conflicting. Most studies have […]

Nonhuman Primate Models of Menopause (Part 17)

Rhesus monkey. Several recent studies have begun to address these concerns. One study examined 178 female rhesus monkeys aged 2-34 yr. No evidence of change with age in total body and spine density was reported; however, small but significant reductions of bone mineral density (BMD) in radial sites were seen. The second study utilized 58 […]

Nonhuman Primate Models of Menopause (Part 16)

Bone Changes Caused by Aging and Menopause This discussion of bone changes caused by aging and menopause is based on presentations by Dr. Mark Lane (Gerontology Research Center, NIA) and Dr. Thomas Clarkson (Wake Forest University School of Medicine). canadian health & care mall

Nonhuman Primate Models of Menopause (Part 15)

Cynomolgus monkey. Surgically postmenopausal cyno-molgus monkeys on an atherogenic diet, like postmenopausal women, had elevated LDL cholesterol, reduced HDL cholesterol, and increased vasoconstrictor response and coronary artery atherosclerosis relative to control, intact monkeys fed the same diet for the same time. Using continuous exposure to physiologic amounts of estrogen, with or without cyclically administered progestin, […]

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