Archive for the ‘Menopause’ Category - Part 2

Nonhuman Primate Models of Menopause (Part 14)

Cardiovascular Changes Preceding and Following Menopause This discussion of cardiovascular changes preceding and following menopause is based on presentations by Dr. K.D. Carey (Southwest Foundation for Experimental Biology) and Dr. Thomas Clarkson (Wake Forest University School of Medicine). Cardiovascular disease is the leading cause of morbidity and mortality in older women. Menopause and aging increase […]

Nonhuman Primate Models of Menopause (Part 13)

Menopausal Hot Flashes This discussion of menopausal hot flashes is based on the presentation by Dr. Robert Freedman (Wayne State University). Rhesus monkeys are excellent models to study the menopausal hot flash, because their reproductive and thermoregulatory systems are very similar to those of humans. Like humans, core body temperature (Tc) in rhesus monkeys is […]

Nonhuman Primate Models of Menopause (Part 12)

Previous studies of metabolic parameters in middle-aged and older female rhesus monkeys generally provided limited documentation of the hormonal profile or their menopausal status. Furthermore, these studies used a cross-sectional rather than a longitudinal experimental design. Therefore, it is impossible to identify the temporal sequence of events in individual animals and their interrelationships with menopause. […]

Nonhuman Primate Models of Menopause (Part 11)

Metabolic Characteristics of Aging Male and Female Monkeys This discussion of the metabolic characteristics of aging in male and female monkeys is based on presentations by Dr Joseph Kemnitz (Wisconsin Regional Primate Research Center) and Dr. K.D. Carey (Southwest Foundation for Biomedical Research). canadian neighbor pharmacy online

Nonhuman Primate Models of Menopause (Part 10)

Because of these limitations, young ovariectomized cy-nomolgus monkeys are currently being used as a model to study the effects of hormonal manipulation on hypothalamic neuropeptide gene expression. This model has the advantages of removing the confounding influence of age and of allowing hormone replacement in regimens that mimic those given to postmenopausal women. These studies […]

Nonhuman Primate Models of Menopause (Part 9)

Current studies using postmortem brain tissue from postmenopausal women may be confirmed and extended in the NHP model. For example, hypertrophied neuronal tissue from the infundibular nucleus of postmenopausal women express estrogen receptor, neurokinin B, and substance P mRNAs. The GnRH gene expression increased in a separate subpopulation of neurons within the medial basal hypothalamus. […]

Nonhuman Primate Models of Menopause (Part 8)

Several ongoing, unpublished neuroendocrine studies related to female reproductive aging in rhesus monkeys at the Oregon Regional Primate Research Centers were described. The LH pulse amplitude of irregularly cycling monkeys was greater than that in premenopausal animals; in postmenopausal monkeys, the LH pulse pattern was similar to that in young, long-term ovariectomized female rhesus monkeys. […]

Nonhuman Primate Models of Menopause (Part 7)

Only the conception rate showed profound age-related differences (20% at 15-25 yr of age and <4% at >35 yr of age). A single P. paniscus , aged more than 40 yr (precise age was unknown, because the animal was captured in the wild when already postmature), was observed to be postmenopausal based on terminated menstrual […]

Nonhuman Primate Models of Menopause (Part 6)

Several reproductive indices measured in wild baboons were similar to those measured in captive animals (unpublished data from the Southwest Foundation for Biomedical Research). Wild and captive baboons both had the same exponential trajectory of adult mortality. Both populations were completely infertile at 25 yr of age. The mean menstrual cycle length for both is […]

Nonhuman Primate Models of Menopause (Part 5)

Baboon. Virtually no information is available in the published literature regarding the menopausal process in baboons. In the baboon, reproductive- and menopause-related research is facilitated by the ability to readily discern menstrual cycle status via the skin color and physical changes of the perineum rather than by the need to rely on blood or urinary […]

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