Archive for the ‘Pneumonia’ Category - Part 2

Effects of Nebulized Diethylenetetraamine-NONOate in a Mouse Model of Acute Pseudomonas aeruginosa Pneumonia: DETA-NO Preparation and Delivery

Mice in the pneumonia and sham groups were randomized to receive nebulized DETA-NO, iNO, or room air (RA). Two doses were studied for both DETA-NO (12.5 or 125 |j,mol; 2.0 or 20 mg, respectively) and iNO (10 or 40 ppm). Thus, the following 10 groups were studied: pneumonia/RA; pneumonia/iNO (10 and 40 ppm); pneumonia/DETA-NO (12.5 […]

Effects of Nebulized Diethylenetetraamine-NONOate in a Mouse Model of Acute Pseudomonas aeruginosa Pneumonia: Materials and Methods

Thus, we hypothesized that nebulized diethyl-enetetraamine-NONOate (DETA-NO), through in-trapulmonary NO release, would have beneficial antibacterial and anti-inflammatory effects in a mouse model of acute P aeruginosa pneumonia. Murine Model of P aeruginosa Pneumonia The experimental protocol was approved by our institutional Animal Care and Use Committee, in accord with the guidelines of the Canadian Council […]

Effects of Nebulized Diethylenetetraamine-NONOate in a Mouse Model of Acute Pseudomonas aeruginosa Pneumonia

Bacterial pneumonia remains a common and important clinical problem. Despite effective antimicrobial therapy, pneumonia has significant morbidity and mortality, especially in hospitalized patients and in those patients with certain pathogens, such as Pseudomonas aeruginosa. Pneumonia is characterized by intrapulmonary bacterial proliferation, pulmonary edema, neutrophil infiltration, and parenchymal lung injury. Therapy targeted at these pathophysiologic features […]

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