Archive for the ‘Pulmonary function’ Category

Contributions of Retinoids to the Generation and Repair of the Pulmonary Alveolus: Retinoids Influence Alveolar Formation

When cultures of rat LIF are supplemented with ATRA, there is a 2.5-fold to threefold increase in the steady-state level of tropoelastin messenger RNA. Tropoelastin is the soluble precursor of elastin, a major component of the elastic fiber. In the lung, its production is normally limited to late gestational and early postnatal life (up to […]

Analysis of the Internal Structure of Peripheral Pulmonary Lesions Using Endobronchial Ultrasonography: EBUS

The average time that required to complete EBUS in 168 patients with peripheral pulmonary lesions was 8.38 min. Fluoroscopy was not able to confirm whether or not the forceps had reached the favorable point for endobronchial brushing and TBB. EBUS cannot create images of healthy air-filled lungs, but it can image peripheral pulmonary lesions because […]

Analysis of the Internal Structure of Peripheral Pulmonary Lesions Using Endobronchial Ultrasonography: Histopathology

The use of miniature ultrasound probes for diagnosing peripheral pulmonary lesions has been reported previously. Hurter and Hanarath reported the successful visualization of peripheral lung lesions in 19 of 26 cases, and Goldberg et al reported that EBUS provided unique information that complement other diagnostic modalities in 18 of 25 cases (including 6 peripheral lesions […]

Analysis of the Internal Structure of Peripheral Pulmonary Lesions Using Endobronchial Ultrasonography: Discussion

Type IIIb, Heterogeneous Pattern Without Hyperechoic Dots and Short Lines: Twenty-two lesions (17.7%) were classified as type IIIb (Fig 11). The majority of lesions (18) were poorly differentiated adenocarcinoma, which had a high cell density and had formed a mass. The lesions were avascular and showed scant mottled or linear hyperechoic areas. The internal echoes […]

Analysis of the Internal Structure of Peripheral Pulmonary Lesions Using Endobronchial Ultrasonography: Heterogeneous Pattern

The density of cancer cells was higher, and the volume of air remaining in the alveoli was smaller in type IIb lesions than in type IIa lesions (ie, well-differentiated adenocarcinoma). The margins were irregular because the lesions grew without any relationship to existing structures. The type IIb group included one case of moderately differentiated adenocarcinoma […]

Analysis of the Internal Structure of Peripheral Pulmonary Lesions Using Endobronchial Ultrasonography: Linear Arcs Pattern

Type Ib, Homogeneous Pattern Without Vessels and Bronchioles: Eight lesions (6.5%) were classified as type Ib (Fig 8). No blood vessels were seen within the lesion by EBUS. Mottled or linear hy-perechoic areas were scant. The internal echoes were homogeneous. Similar to the situation with type Ia lesions, ultrasound attenuation was small, and even tissue […]

Analysis of the Internal Structure of Peripheral Pulmonary Lesions Using Endobronchial Ultrasonography: Homogeneous Pattern

In three of four cases of small cell carcinoma, the tumors had directly invaded the pulmonary artery adjacent to the affected bronchus, resulting in stenosis of the pulmonary artery within the lesion (Fig 5). In three cases, carcinoid tumors had grown out of the bronchial lumen across the bronchial wall, resulting in a characteristic snowman-like […]

Analysis of the Internal Structure of Peripheral Pulmonary Lesions Using Endobronchial Ultrasonography: Results

Correlation Between EBUS Images and the Histopathology The data from the 69 patients in whom preoperative EBUS images could be correlated with the histopathologic findings of surgical specimens were available for analysis (Table 1). Of the 18 cases of well-differentiated adenocarcinoma, EBUS showed the preservation of blood vessels within the lesion in 7 (Fig 2). […]

Analysis of the Internal Structure of Peripheral Pulmonary Lesions Using Endobronchial Ultrasonography: Methods and Equipment

Correlation Between the Preoperative EBUS Images and the Histopathologic Findings: Bronchoscopy was performed with a flexible bronchoscope under local anesthesia without sedation. The miniature probe was inserted into bronchi that were suspected to lead to the lesions visualized by plain roentgenography or CT scanning. The probe was introduced up to the point at which the […]

Analysis of the Internal Structure of Peripheral Pulmonary Lesions Using Endobronchial Ultrasonography

Numerous reports have shown that high’ frequency, two-dimensional ultrasonography is a useful technique for evaluating the depth of invasion of gastrointestinal tumors, for detecting lymph node metastasis, and for identifying coronary stenosis and thrombosis. Since 1994, our facility has worked on the development of endobronchial ultrasonography (EBUS). EBUS uses a miniature probe inserted through the […]

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