Archive for the ‘Pulmonary function’ Category - Part 12

Bronchoalveolar Lavage in Liquid Paraffin Pneumonitis: Results (5)

BALF Biochemical Analysis After overnight decantation or low-speed centrifugation, the BALF from the patients with liquid paraffin pneumonitis often was separated into an upper oily layer and a lower clearer phase. The upper layer represented a small fraction, less than 20 percent of the 10 ml aliquot protein. Protein content was increased in the lower […]

Bronchoalveolar Lavage in Liquid Paraffin Pneumonitis: Results (4)

Morphologic and Histochemical Evaluation of Alveolar Macrophages The AM from liquid paraffin pneumonitis demonstrated morphologic abnormalities. Nearly all the AM had a foamy appearance because the cytoplasm was full of numerous, large, rounded vacuoles (Fig 2). These optically empty vacuoles were not stained with the May-Grunwald-Giemsa, Papanicolaou or PAS. Vacuoles were weakly stained in black […]

Bronchoalveolar Lavage in Liquid Paraffin Pneumonitis: Results (3)

BALF Cell Populations in Liquid Paraffin Pneumonitis The BALF recovered from the seven patients with liquid paraffin pneumonitis was whitish and turbid with many oil droplets on the surface. The percentage of recovery was greater than 40 percent of the injected fluid for the seven patients (Table 2). ventolin inhalers

Bronchoalveolar Lavage in Liquid Paraffin Pneumonitis: Results (2)

The sedimentation rate was increased between 37 and 76 (mean 55) for the seven patients. Serum protein analysis, electrolytes, hepatic and renal test results were normal. The tests for immune complexes and markers of autoimmune disease were negative except for patient 6 with chronic aggressive hepatitis. The Pa02 measured for five patients was markedly decreased […]

Bronchoalveolar Lavage in Liquid Paraffin Pneumonitis: Results (1)

Patient Population with Liquid Paraffin Pneumonitis The seven nonsmokers (four women and three men) between 56 and 87 years old (mean 69) were hospitalized for chronic pneumonitis (Table 1). None had any known respiratory disease in their past medical history. A neurologic or psychiatric disorder was present in four of them: chronic psychosis treated with […]

Bronchoalveolar Lavage in Liquid Paraffin Pneumonitis: Methods (2)

Electron microscopic examination was performed after fixation of the cell pellet for one hour with 3 percent glutaraldehyde and washing in phosphate buffer pH 7.3. The cells were subsequently postfixed in 2 percent osmium tetraoxide in phosphate buffer pH 7.3. Ultrathin sections of representative regions chosen from semithin sections were prepared and examined using an […]

Bronchoalveolar Lavage in Liquid Paraffin Pneumonitis: Methods (1)

BaHent Population A bronchoalveolar lavage was performed in seven patients with liquid paraffin pneumonitis, seven patients with pulmonary alveolar proteinosis, and ten healthy nonsmoker subjects. Bronchoalveolar Lavage Bronchoalveolar lavage was performed (after informed consent) with five successive fractions of 50 ml saline solution injected at room temperature through a fiberoptic bronchoscope. The small amount of […]

Bronchoalveolar Lavage in Liquid Paraffin Pneumonitis

Iaughlen first reported in 1925 four cases of lipoid pneumonitis following the use of mineral oil for nose drops or laxatives. Three of his cases occurred in young children and one in an adult with soft palate and vocal cord paralysis. Two years later, Pinkerton2 described six children with lipoid pneumonitis following the use of […]

A Double-Blind Multicenter Group Comparative Study of the Efficacy and Safety of Nedocromil Sodium in the Management of Asthma: Discussion (3)

The present study is the longest controlled trial of nedocromil sodium. The effect of reducing concomitant bronchodilator therapy while patients are receiving nedocromil sodium has been assessed in other multicenter trials,’ but these have been of four or six weeks’ duration. In common with the present study, these have evaluated the efficacy of the four […]

A Double-Blind Multicenter Group Comparative Study of the Efficacy and Safety of Nedocromil Sodium in the Management of Asthma: Discussion (2)

During weeks 3 to 6, when SRTs were no longer part of the patients’ treatment and oral bronchodilator medication was minimal, there were statistically significant differences in favor of nedocromil sodium for virtually every diary card and clinic variable. The nedocromil sodium-treated group was able to maintain, with the exception of night-time asthma, the improvement […]

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