Archive for the ‘Pulmonary function’ Category - Part 13

A Double-Blind Multicenter Group Comparative Study of the Efficacy and Safety of Nedocromil Sodium in the Management of Asthma: Discussion (1)

The data presented indicate a beneficial effect of nedocromil sodium in adult patients with asthma — buy asthma inhaler. Neither the severity of the asthma nor the atopic status of the patients appeared to be a factor in this response. The results from the first two weeks of this study indicate that the addition of […]

A Double-Blind Multicenter Group Comparative Study of the Efficacy and Safety of Nedocromil Sodium in the Management of Asthma: Results (6)

Figure 5 indicates the changes in FEV, at clinic visits. The changes in FVC and PEFR are given in Table 5. Measurements at all clinic visits showed highly significant between treatment differences (p^O.Ol). Pulmonary function increased from baseline in the nedocromil sodium-treated group and decreased from baseline for the placebo-treated patients at all clinic visits. […]

A Double-Blind Multicenter Group Comparative Study of the Efficacy and Safety of Nedocromil Sodium in the Management of Asthma: Results (5)

Pulmonary Function The changes in clinic and diary card pulmonary function data were consistent across the centers and the data were pooled for analysis. buy prednisone

A Double-Blind Multicenter Group Comparative Study of the Efficacy and Safety of Nedocromil Sodium in the Management of Asthma: Results (4)

Clinic assessment of asthma severity was similar between the two treatment groups at the end of the baseline (Table 3). There was a statistically significant difference (p = 0.01) in favor of the nedocromil sodium-treated patients by the end of week 2, ie, before the withdrawal of SRT, with a mean improvement from baseline of […]

A Double-Blind Multicenter Group Comparative Study of the Efficacy and Safety of Nedocromil Sodium in the Management of Asthma: Results (3)

Although concomitant medication use (Fig 3) was not statistically significantly different (p = 0.34) between treatment groups during the baseline, the nedocromil sodium patients used more SRT (one half unit dose per day). The j$2 use was virtually the same for both groups, with approximately 70 percent of the total daily dose taken during the […]

A Double-Blind Multicenter Group Comparative Study of the Efficacy and Safety of Nedocromil Sodium in the Management of Asthma: Results (2)

Primary Efficacy Variables The changes in diary card symptom scores were consistent across the centers, with the exception of night-time asthma for treatment weeks 1 to 2 (p = 0.01). The data have been pooled for analysis. The cumulative daily mean symptom score analysis (Fig 1) showed statistically significant differences in favor of nedocromil sodium […]

A Double-Blind Multicenter Group Comparative Study of the Efficacy and Safety of Nedocromil Sodium in the Management of Asthma: Results (1)

Treatment Group Comparability, Compliance and Withdrawals Analysis of the baseline and disease history data showed close comparability between the treatment groups within and across centers. Across the centers, the placebo group had significantly more female subjects (p = 0.005) and significantly fewer patients receiving immunotherapy (p = 0.03), but there were no significant differences in […]

A Double-Blind Multicenter Group Comparative Study of the Efficacy and Safety of Nedocromil Sodium in the Management of Asthma: Methods (4)

Analyses were performed for weeks 1 to 2, 3 to 6, and 7 to 14. The primary variables were diary card symptom scores, concomitant bronchodilator use, clinician assessment of asthma severity, and clinician and patient opinion of study treatment. Cough scores were analyzed for all patients, and separately, for those patients who recorded cough (score>0.5) […]

A Double-Blind Multicenter Group Comparative Study of the Efficacy and Safety of Nedocromil Sodium in the Management of Asthma: Methods (3)

The SRTs were withheld for 24 hours and other bronchodilators for six hours prior to these tests, and visits were scheduled, where possible, for the same time of day. Patients were questioned about any adverse treatment experiences. At the final visit, blood and urine samples were taken, and clinicians and patients assessed the effectiveness of […]

A Double-Blind Multicenter Group Comparative Study of the Efficacy and Safety of Nedocromil Sodium in the Management of Asthma: Methods (2)

Patients receiving immunotherapy remained at the same dose throughout. During the baseline and first two weeks of the treatment period, patients used their SRT and p* preparations. The SRT was then withdrawn. After six weeks on trial treatments, oral 02 wa$ withdrawn and inhaled p2 was to be used only when the study drug failed […]

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