Archive for the ‘Pulmonary function’ Category - Part 2

Contributions of Retinoids to the Generation and Repair of the Pulmonary Alveolus: Conclusion

In summary, RAR-^-/-mice demonstrate biochemical, anatomic and physiologic characteristics of emphysema at postnatal week 4. The time course of the development of the emphysematous phenotype is similar to that observed in the tight-skinned mouse, another genetic model of congenital emphysema resulting from a duplication within the coding region of the fibrillin-1 gene.11 These data indicate […]

Contributions of Retinoids to the Generation and Repair of the Pulmonary Alveolus: RA

Studies using cultured LIF indicate that the levels of RAR-p and RAR-7 increase at birth, at the same time that these cells contain their maximal amount of RA.9 The increase in RAR-7 was transient, decreasing after postnatal day 2 (when endogenous LIF RA also decreases), suggesting that RA may signal transiently through RAR-7 to influence […]

Contributions of Retinoids to the Generation and Repair of the Pulmonary Alveolus: Lung Explants

During the second postnatal week, they may comprise up to 25% of alveolar cells. The lipids are primarily neutral lipids that are acquired, much like adipocytes, but they also contain retinyl esters. Retinyl esters are most abundant during late gestation in the rat, and their content decreases after birth. This decrease in endogenous LIF retinyl […]

Contributions of Retinoids to the Generation and Repair of the Pulmonary Alveolus

During the last 4 years, there has been a renewed interest in strategies directed at the restoration of the alveolar surface area and the respiratory and mechanical function of the lung parenchyma. Retinoids have received considerable attention as alveolar morphogens and potential therapeutic agents, after retinoic acid was shown to ameliorate the emphysema that was […]

Pulmonary and Extrapulmonary Effects of Increased Colloid Osmotic Pressure During Endotoxemia in Rats: Pulmonary edema

Guyton and Lindsey demonstrated that when plasma COP was reduced by half, the threshold hydrostatic pressure necessary for the formation of pulmonary edema fell from 25 to 13 mm Hg. An increase in the hydrostatic pressure above a threshold appears to be a prerequisite for edema formation. When capillary permeability is increased, the transvascular oncotic […]

Pulmonary and Extrapulmonary Effects of Increased Colloid Osmotic Pressure During Endotoxemia in Rats: Discussion

Because the primary aim of our experiment was to investigate the effect of high COP on fluid redistribution, we used an equal fluid volume for both the saline solution-treated and the albumin-treated groups. Thus, the present data may not be extrapolated to the clinical situations involving fluid resuscitation. Furthermore, the albumin-treated groups in our study […]

Pulmonary and Extrapulmonary Effects of Increased Colloid Osmotic Pressure During Endotoxemia in Rats: Organ Water Content

Ileum and liver water content was not significantly different in any group (saline solution-treated rats: liver, 72.3 ± 1.0%; ileum, 76.2 ± 0.87). In contrast, however, significant differences were observed for the lung, the kidneys, and the heart among the various groups (Fig 7). Lung water content increased significantly in the endotoxemic rats (group III) […]

Pulmonary and Extrapulmonary Effects of Increased Colloid Osmotic Pressure During Endotoxemia in Rats: Results

Group II Experiments in this group were completed in 10 of 11 rats, the results showed stable gas-exchange and acid-base balances (Table 2). The infusion of the three single doses of 1 g/kg human albumin was associated with a gradual and significant increase in COP up to a maximum of 58% (Fig 1). In this […]

Pulmonary and Extrapulmonary Effects of Increased Colloid Osmotic Pressure During Endotoxemia in Rats: Determination of Organ Water Content

After the last data collection (at 6 h), all rats were killed with IV administration of pentobarbital, following which the kidneys, lung, heart, liver, and a 15-cm section of the ileum in each rat were quickly removed. Tissues were weighed and then placed in an oven at 60°C for slow drying for > 5 days. […]

Pulmonary and Extrapulmonary Effects of Increased Colloid Osmotic Pressure During Endotoxemia in Rats:

This dose of heparin also prevents blood coagulation in samples used for gas-exchange analyses or COP determination. However, to minimize the possible interaction of heparin with the endotoxin, we used a reduced dose of 100 U/kg/2 h IV. Assuming that the presence of heparin can block the activity of endotoxin, it may then equally affect […]

Pages: Prev 1 2 3 4 5 6 7 8 9 10 ... 12 13 14 Next
anosiahuman.com