Archive for the ‘Sarcoidosis’ Category

Serum Concentration of Soluble lnterleukin-2 Receptor as a Sensitive Parameter of Disease Activity in Sarcoidosis (9)

Elevated levels of both serum IL-2R and ACE activity of one of our patients with dormant sarcoidosis described previously might be due to some granulomatous lesions that were not manifested by clinical examinations or chest x-ray film studies. Extensive investigations including gallium 67 or BAL analysis seem to be needed for the follow-up in these […]

Serum Concentration of Soluble lnterleukin-2 Receptor as a Sensitive Parameter of Disease Activity in Sarcoidosis (8)

In corticosteroid-treated patients, it rapidly decreased to normal range within four weeks after initiation of the therapy. We also observed a correlation between serum concentration of soluble IL-2R and serum ACE activity, and the association noted in our study was stronger than that reported previously. Serial measurements of those two parameters in patients with spontaneous […]

Serum Concentration of Soluble lnterleukin-2 Receptor as a Sensitive Parameter of Disease Activity in Sarcoidosis (7)

The second patient was a 55-year-old woman who developed neurologic and eye symptoms due to sarcoidosis. Corticosteroid therapy was begun with an initial dosage of 30 mg of prednisolone per day, and serum concentration of soluble IL-2R decreased rapidly to the normal range within four weeks, accompanied by improvement of her symptoms and a decrease […]

Serum Concentration of Soluble lnterleukin-2 Receptor as a Sensitive Parameter of Disease Activity in Sarcoidosis (6)

No obvious dissociation between these two parameters was noted in patients with untreated sarcoidosis. Correlation of Soluble IL-2R in Serum with Some Parameters of BAL Fluid The relationship between soluble IL-2R concentration and some parameters of BAL fluid was studied in nine cases with active sarcoidosis, and no apparent association was observed between serum concentration […]

Serum Concentration of Soluble lnterleukin-2 Receptor as a Sensitive Parameter of Disease Activity in Sarcoidosis (5)

Results Serum Concentrations of Soluble IL-2R in Active, Dormant and Corticosteroid-Treated Sarcoidosis Serum concentrations of soluble IL-2R were compared among the three groups described previously. The mean value of soluble IL-2R concentrations in serum samples from 34 patients with active untreated sarcoidosis was 1,143 U/ml and that for 30 patients with dormant sarcoidosis was 353 […]

Serum Concentration of Soluble lnterleukin-2 Receptor as a Sensitive Parameter of Disease Activity in Sarcoidosis (4)

Assay for Serum Angiotensin Converting Enzyme Activity The level of serum ACE activity was determined by the modified spectrophotometric assay of Cushman and Cheung as described previously. The values of less than 40 U/ml were considered normal.

Serum Concentration of Soluble lnterleukin-2 Receptor as a Sensitive Parameter of Disease Activity in Sarcoidosis (3)

Assay for Soluble IL-2R in Serum Measurement of serum concentrations of soluble IL-2R was performed by using commercially available Celfree Interleukin-2 Receptor Bead Kit (T Cell Sciences Inc, Cambridge, MA). This assay system is a two-site, solid-phase enzyme immunometric assay which employs two noncompeting monoclonal antibodies to the human IL-2Ra chain. Briefly, each 50 jjlL […]

Serum Concentration of Soluble lnterleukin-2 Receptor as a Sensitive Parameter of Disease Activity in Sarcoidosis (2)

The serum level of soluble IL-2R was also shown to be elevated in sarcoidosis, presumably reflecting the activated T-lymphocytes in this disease. We measured serum concentrations of soluble IL-2R to estimate its clinical usefulness in monitoring sarcoidosis. buy prednisone

Serum Concentration of Soluble lnterleukin-2 Receptor as a Sensitive Parameter of Disease Activity in Sarcoidosis (1)

Although sarcoidosis is self-limited in most cases, some instances of the disease are progressive and occasionally fatal. Therefore, monitoring disease activity is of great importance in the management of this disease. Disease activity of sarcoidosis currently has been assessed by clinical status, chest x-ray film findings, pulmonary function tests, gallium 67 scans, BAL findings or […]

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