Category: Sarcoidosis

Serum Concentration of Soluble lnterleukin-2 Receptor as a Sensitive Parameter of Disease Activity in Sarcoidosis (8)

In corticosteroid-treated patients, it rapidly decreased to normal range within four weeks after initiation of the therapy. We also observed a correlation between serum concentration of soluble IL-2R and serum ACE activity, and the association noted in our study was stronger than that reported previously. Serial measurements of those two parameters in patients with spontaneous remission or those treated with steroids showed that the change…

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Serum Concentration of Soluble lnterleukin-2 Receptor as a Sensitive Parameter of Disease Activity in Sarcoidosis (7)

Serum Concentration of Soluble lnterleukin-2 Receptor as a Sensitive Parameter of Disease Activity in Sarcoidosis (7)

The second patient was a 55-year-old woman who developed neurologic and eye symptoms due to sarcoidosis. Corticosteroid therapy was begun with an initial dosage of 30 mg of prednisolone per day, and serum concentration of soluble IL-2R decreased rapidly to the normal range within four weeks, accompanied by improvement of her symptoms and a decrease in serum ACE activity (Fig 3B). A similar rapid decrease…

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Serum Concentration of Soluble lnterleukin-2 Receptor as a Sensitive Parameter of Disease Activity in Sarcoidosis (6)

Figure-3

No obvious dissociation between these two parameters was noted in patients with untreated sarcoidosis. Correlation of Soluble IL-2R in Serum with Some Parameters of BAL Fluid The relationship between soluble IL-2R concentration and some parameters of BAL fluid was studied in nine cases with active sarcoidosis, and no apparent association was observed between serum concentration of soluble IL-2R and the percentage of lymphocytes (r=0.07) or…

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Serum Concentration of Soluble lnterleukin-2 Receptor as a Sensitive Parameter of Disease Activity in Sarcoidosis (5)

Figure-1

Results Serum Concentrations of Soluble IL-2R in Active, Dormant and Corticosteroid-Treated Sarcoidosis Serum concentrations of soluble IL-2R were compared among the three groups described previously. The mean value of soluble IL-2R concentrations in serum samples from 34 patients with active untreated sarcoidosis was 1,143 U/ml and that for 30 patients with dormant sarcoidosis was 353 U/ml, and the difference was highly significant (p<0.001; Fig 1),…

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Serum Concentration of Soluble lnterleukin-2 Receptor as a Sensitive Parameter of Disease Activity in Sarcoidosis (3)

Serum Concentration of Soluble lnterleukin-2 Receptor as a Sensitive Parameter of Disease Activity in Sarcoidosis (3)

Assay for Soluble IL-2R in Serum Measurement of serum concentrations of soluble IL-2R was performed by using commercially available Celfree Interleukin-2 Receptor Bead Kit (T Cell Sciences Inc, Cambridge, MA). This assay system is a two-site, solid-phase enzyme immunometric assay which employs two noncompeting monoclonal antibodies to the human IL-2Ra chain. Briefly, each 50 jjlL of serum sample was incubated with a plastic bead coated…

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Serum Concentration of Soluble lnterleukin-2 Receptor as a Sensitive Parameter of Disease Activity in Sarcoidosis (1)

Serum Concentration of Soluble lnterleukin-2 Receptor as a Sensitive Parameter of Disease Activity in Sarcoidosis (1)

Although sarcoidosis is self-limited in most cases, some instances of the disease are progressive and occasionally fatal. Therefore, monitoring disease activity is of great importance in the management of this disease. Disease activity of sarcoidosis currently has been assessed by clinical status, chest x-ray film findings, pulmonary function tests, gallium 67 scans, BAL findings or serum ACE levels, Chest roentgenogram and BAL findings may reflect…

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