Diethylstilbestrol Versus Estradiol: DISCUSSION(6)


The uteri and cervices of the prenatally DES-exposed mice exhibited the same hypertrophic/hyperplastic/hyperestrogenic qualities that we observed in the neonatally DES-exposed hamsters, whereas those of the neonatally DES-exposed mice were hypotrophic. Thus, we conclude that 1) in addition to the differential effects observed in the prepubertal cervix, neonatal DES, but not E2, treatment induces long-term hy-perestrogenic changes in the cervix of adult, intact hamsters and 2) treatment of hamsters once on the day of birth with DES approximates the situation in which mice are treated repeatedly with DES during the mid to late stages of gestation.

In adult hamsters under the O+E2 conditions, we were surprised in the present study to find that their cervical regions were of similar size and histology in all three treatment groups, whereas in both the present and a previous study, their uteri were hypertrophic and hyperplastic/ dysplastic in the DES-treatment group only. In other words, neonatal DES, but not E2, treatment directly elicits a hy-perestrogenic effect in the early, developing (prepubertal) cervix and uterus, but it has differential effects on the two regions when the adult tract is chronically stimulated with estrogen.