Diethylstilbestrol Versus Estradiol: DISCUSSION(8)

In conclusion, both the early and long-term development of the cervix in intact hamsters was differentially disrupted by neonatal exposure to the same high dose of DES versus E2. The extent of this phenomenon in adult animals may be caused, at least in part, by differing degrees of altered ovarian function between the two neonatal treatment groups. However, the mechanisms and ovarian agents responsible for differential disruption in the postpubertal cervix are not yet known.

Relevant to this topic, and in contrast to what was found in the hamster uterus, the response of the adult hamster cervix to chronic estrogen stimulation did not differ between the two neonatal treatment groups or between the two neonatal treatment groups and the control group. Future efforts in this experimental system should use a range of lower, environmentally relevant doses of DES, E2, plus other suspected EDs and should continue to probe for differences in molecular dynamics among specific reproductive tract regions (cervix, uterus, oviduct, and ovary). new asthma inhaler