Elevated Pulmonary Artery Pressure: Results (Part 3)

These findings further demonstrate that pulmonary vascular resistance was not a key contributing factor in the prediction of mortality. Given the low predictive value of these variables, and their elimination from the stepwise model, they were not included in subsequent analyses. Inclusion of LV mass in a multivariate regression model yielded independent significance for PAMP, LV mass, and number of vessels, with respective p values of <0.01, 0.03, and 0.05. The standardized (3-coefficients in this analysis were 3.9 for PAMP and 2.2 for LV mass. The mortality risk associated with PAMP was thus entirely independent of the effect of increasing severity of LVH. ventolin 100 mcg
To assess further the relative contribution of PAMP in relation to the level of LV systolic function, Cox regression analysis was performed separately in patients with and without depressed LV function (Table 4). In patients with normal LV function (ie, LVEF>50), PAMP was confirmed as a powerful predictor of outcome along with ejection fraction, followed by number of stenosed vessels. Similarly, in patients with a reduced ejection fraction, PAMP provided the most explanatory information regarding outcome, followed by the number of stenosed vessels; the contribution of ejection fraction did not reach statistical significance in this subgroup.

Table 4—Cox Stepwise Regression Analysis of Determinants of Survival after Cardiac Catheterization: By Level of Left Ventricular Function

Patients with Normal Ejection Fraction >50% (N = 1118; 64 fatal events)
Variable X p value
PAMP 15.6 .000
Ejection fraction 12.7 .000
No. of vesselst 5.2 .023
Patients with Reduced Ejection Fraction <50%
(N = 253; 39 fatal events) Improvement
Variable X p value
PAMP 6.70 .010
No. of vessels 5.21 .023

Category: Pulmonary function

Tags: ejection fraction, hypertrophy, pulmonary artery pressure, pulmonary pressure, systolic function