Human gastric mucosal hydrophobicity and Helicobacter pylori infection

endoscopic antral biopsy samplesThe hydrophobic or water-repellent mucus lining of the stomach plays an important role in protecting the gastric mucosa from acid and peptic digestion . In 1983, it was reported that canine gastric mucosa has clear hydrophobic properties as determined by contact angle analysis. Since this observation, reports from many investigators have indicated that the stomach of all mammalian species tested, including humans, have nonwettable properties that appear to be attributable to the hydrophobic characteristics of the overlying mucus gel layer. Goggin et al and Spychal et al used a technique that permitted contact angle analysis of endoscopic antral biopsy samples.

The hydrophobicity of the gastric antral mucosa of peptic ulcer patients has been found to be significantly lower than that of healthy volunteers . The effect of Helicobacter pylori on human mucosal hydrophobicity has been investigated using the contact angle technique, with most studies reporting a decrease in mucosal hydrophobicity with H pylori infection compared with noninfected controls. In contrast, Day et al have shown that H pylori (mouse-adapted strain SS1) had no effect on the gastric mucus surface hydrophobicity in C57BL/6 and gld mice despite mucosal inflammation. The aim of the present study was to differentiate between the effect of H pylori cytotoxin-associated gene A (cagA)+ and cagA-strains on human gastric mucosal hydrophobicity. Best quality drugs are available at the best pharmacy that you can start shopping with right now whenever you need buy alesse, never having to doubt the choice made or the quality of the drug you get.