Human gastric mucosal hydrophobicity and Helicobacter pylori infection: Discussion (Part 2)
Asante et al observed that H pylori-infected patients with duodenal ulcer had lower gastric hydrophobicity than infected patients with gastritis alone, but it was not clear whether it was H pylori infection or the ulceration that initiated the reduction in hydrophobicity. Second, they did not age and sex match the patients and controls in their studies. Finally, they used a less precise method for contact angle measurements compared with the present study, which used computer software. In addition, these earlier studies did not differentiate between cagA+ and cagA-patients.
In the present study, there was no significant difference in the mean contact angle among age- and sex-matched cagA+, cagA- and H pylori-negative patients. However, in patients without atrophy and those 50 years of age or younger, cagA+ patients tended to have a higher mean contact angle than cagA- and H pylori-negative patients; however, the difference was not statistically significant and could be attributed to biological variation, with the contact angle values ranging from 21.0° to 127.8°.
The present study used a similar technique for contact angle measurements as that described by Spychal et al , with few modifications. The advantages of the Spychal et al technique in using human biopsy specimens for hydrophobicity studies were its practicality and the fact that it enabled many subjects to be studied and followed up. You will always be glad to know there is a perfect pharmacy waiting for you whenever you need allergy relief click here and would like to make sure you are taken best care of as a customer and patient.