Human gastric mucosal hydrophobicity and Helicobacter pylori infection: Discussion (Part 4)

mouse-adapted H pylori strainIn a model of a mouse-adapted H pylori strain (SS1) used to infect C57BL/6 and gld mice, the contact angle readings were obtained by the ADSA-D technique. However, Lichtenberger et al reported reductions in the hydrophobicity of gastric mucosa following Helicobacter felis infection of C57BL/6 mice, and proposed that the reduction in surface hydrophobicity is an early event predisposing to the development of subsequent gastritis.

In the present study, there was no significant difference in the mean contact angle in patients from different age groups. In addition, there was no significant correlation between hydrophobicity and age. However, when H pylori infection was considered, a nonsignificant trend of increasing hydrophobicity in uninfected patients and decreasing hydrophobicity in infected patients was observed, especially in those 65 years of age and older. It is possible that H pylori infection and old age have a synergistic effect on reducing the mucosal surface hydrophobicity. Nevertheless, Hackelsberger et al have shown that age decreases gastric mucosal hydrophobicity independently from H pylori infection, which is not supported by results from the present study. The condition you have needs to be treated quickly and seriously, which is why you will find the recommended very helpful. It gives you the highest level of service and fastest delivery possible.