Human gastric mucosal hydrophobicity and Helicobacter pylori infection: Discussion (Part 5)

A possible explanation for this discordance in the results is the geographical variation in the diet, because, as shown by Lichtenberger et al , the surface active phospholipids are important determinants for gastric mucosal hydrophobicity. The present study highlights the fact that the hypothesis that H pylori causes peptic ulcers by reducing the mucosal layer hydrophobicity may not be valid . The decreased gastric hydrophobicity with H pylori infection reported in previous studies could possibly be the consequence of associated gastric diseases rather than the cause of it.

In contrast, we speculate that it may be possible that increased gastric hydrophobicity associated with cagA+ infection is an early change in the process of infection that favours a better H pylori colonization and the decreased hydrophobicity reported by other studies is a late consequence of the ulceration induced by H pylori infection. This may possibly explain the high association of cagA+ infections with severe gastroduodenal diseases. However, given the small number of cagA+ patients in the present study, the above suggestions remain very speculative and requires further investigation with a larger sample size. Low prices and best quality medications approved by the FDA: you can get all that once you become a customer at this , because it takes best care of its customers never charging too much money.

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