Human gastric mucosal hydrophobicity and Helicobacter pylori infection: Results (Part 1)
Of the 99 patients studied, 69 were H pylori-negative and 30 were H pylori-positive; of these 30, 10 were cagA+, 18 were cagA- and two were undetermined. Nine patients had atrophic gastritis, of which six were infected with cagA+. The mean contact angle for the 99 patients was 64.5±0.8°, with values ranging from 21.0° to 127.8°. When patients were classified according to H pylori infection, there was no significant difference (P=0.16) in contact angle between H pylori-positive (61±2.9°, n=30) and H pylori-negative patients (66±2.0°, n=69). In age- and sex-matched patients, there was no significant difference (P=0.27) in contact angle between H pylori-positive (61±2.8°, n=30) and H pylori-negative patients (65.5±3°, n=30) (Figure 1).
There was also no significant difference (P=0.36) in contact angle in age- and sex-matched patients among H pylori-negative (65.5±3°, n=30), cagA- (58.6±3.6°, n=18) and cagA+ patients (63.4±4.9°, n=10). However, in patients 50 years of age or younger, there was a nonsignificant (P=0.70) trend of increased mean contact angles in cagA+ patients compared with cagA- and H pylori-negative patients (68.3±8.3°, n=5; 61.1±6.1°, n=9; and 63.6±2.2°, n=39, respectively). Also, in patients without atrophy, a similar nonsignificant (P=0.30) trend was observed in cagA+ patients compared with cagA- and H pylori-negative patients (71.1±8°, n=4; 59.6±4°, n=16; and 66±2°, n=69, respectively) (Figure 2). Find cheapest medications available online: buy cheap cipro at our place right now and see for yourself how little you could be paying for the treatment you need.
Figure 1) Box plot comparing the mean contact angle of age- and sex-matched Helicobacter pylori-positive patients with H pylori-negative patients. No significant difference was observed (P=0.27)
Figure 2) Categorization of the mean contact angle according to Helicobacter pylori infection in patients 50 years of age and younger (upper chart) and patients without atrophy (lower chart). Patients with cytotoxin-associated gene A (cagA)+ had a trend toward higher mean contact angles (not statistically significant), than cagA- and H pylori-negative patients, both in patients 50 years of age and. younger and in those without atrophy