Human gastric mucosal hydrophobicity and Helicobacter pylori infection: Results (Part 3)

severity of gastritisTo determine the impact of the severity of gastritis on the surface hydrophobicity measurements, the mean contact angle was compared in groups of patients with normal histology and those with different grades of gastritis based on antral histology. There was no significant difference (P=0.599, one-way ANOVA) between the groups. In addition, when both the factors of gastritis and the infecting H pylori strain were considered, their interaction had no significant effect on the mean contact angle readings (P=0.368, two-way ANOVA).

The contact angle measurements for the first 22 patients were repeated twice (six readings on each occasion) to assess intraobserver repeatability. There was no evidence of bias between the two measurements (P=0.950, paired Student’s t test).

The stomachs of all mammalian species, including humans, have nonwettable properties that appear to be attributed to the hydrophobic characteristics of the overlying mucus gel layer . The hydrophobic mucus lining of the stomach plays an important role in gastric cytoprotection. Lichtenberger et al have shown that rats injected with prostaglandin E2 had higher gastric mucosal concentrations of phospholipids and surfactants than controls, indicating the importance of prostaglandin E2 in enhancing gastric hydrophobicity. High quality medications available at best pharmacy that will make sure you are comfortable and secure when buying allergy medications at our place or any other medicine that you need at any point.


Category: Gastric mucosal hydrophobicity

Tags: Age, CagA+, Gastric, Helicobacter pylori, Hydrophobicity