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Human gastric mucosal hydrophobicity and Helicobacter pylori infection: Subjects

One hundred patients were randomly recruited from endoscopy clinics in the North of England without prior knowledge of their H pylori status. The study was approved by the Leeds Health Authority clinical research ethics committee and the York research ethics committee. Written consent was obtained from and information sheets given to each patient. Patients were included in the study if they were not taking acid suppressive drugs, nonsteroidal anti-inflammatory drugs or receiving treatment for H pylori, but excluded if they were known or found to have peptic ulcer disease or gastric cancer (to eliminate the possible effects of previous pathologies on the surface hydrophobicity). Following recruitment into the study, one patient was subsequently excluded due to the presence of duodenal ulcer. Of the remaining 99 patients, 42 (42%) were male and 57 (58%) female with mean ages of 46±11 and 51±15 years, respectively. Six biopsies were taken from each patient (five from the antrum and one from the body of the stomach). Of the six biopsies, one was used for the measurement of gastric mucosal hydrophobicity (taken from the greater curvature), one was for polymerase chain reaction (PCR), one was for culture of H pylori, one was for the Campylobacter–like organism test and two were examined for histology (antrum and body). You will always be glad to find asthma inhalers and enjoy your online shopping.