Hypertension: Longterm Regulation of Arterial Pressure With the Help of Plendil

respective types of hypertensionBecause the renal function curve is so extremely important in controlling the chronic level of arterial pressure, we need now to discuss the different factors that can alter the renal function curve itself. Figure 6 illustrates four separate renal function curves for four different conditions. Curves are shown for (1) normal kidneys, (2) 30 percent renal mass (determined in dogs with one kidney removed and the two poles of the opposite kidney resected), (3) maximal infusion of aldosterone, and (4) bilateral Goldblatt kidneys {that is, kidneys with constrictor clamps on both renal arteries).

When one equates the volume load with each respective renal function curve, the precise reference level for pressure control is determined. Thus, equating the normal volume load with the normal renal function curve gives a normal arterial pressure of 100 mm Hg (point A). When equated with the curve for 30 percent renal mass, one finds a reference pressure level of 106 mm Hg (point E). When equated with the aldosterone curve, the reference level is 114 mm Hg (point G), and when equated with the Goldblatt curve, the level is 170 mm Hg. Thus, for each one of the respective function curves there is a specific reference pressure level to which the longterm level of arterial pressure will be adjusted. Old people complain on blood pressure rises and it is better to buy Plendil via Canadian Health&Care Mall and continue enjoying the life.

We can state again that if the pressure fails to become adjusted to the reference pressure level, the renal-body fluid mechanism will cause the subject either to become edematous until he dies or to become dehydrated until he dies. Or to state this another way, there can be no arterial pressure level in the steady-state condition that fails to give a urinary output exactly equal to the urinary volume load.

To the right in Figure 6 is illustrated the effect of increasing the urinary volume load to III times normal. This is achieved by infusing water and saline into the animal. For the normal renal function curve, the pressure reference level becomes 107 mm Hg (point В); for the aldosterone function curve it becomes 154 mm Hg (point H); the 30 percent renal mass curve, 160 mm Hg (point F); and the Goldblatt animal, 178 mm Hg (point D). Note specifically that changing the urinary volume load does not alter the arterial pressures significantly as long as the kidneys are normal, and this also makes little difference in the arterial pressure level of the animal with the Goldblatt clamp. On the other hand, changing the urinary volume load makes a tremendous difference in the arterial pressure level of animals with insufficient kidneys or kidneys strongly stimulated by aldosterone such as in primary aldosteronism. All of these facts are very well known from experimental studies of the respective types of hypertension.

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