Impact of Integrative Cardiopulmonary Exercise Testing (19)

Finally, as noted, different investigations have suggested that resting LV filling pressure, as estimated from pulmonary capillary wedge pressure, may or may not be strongly associated with measured exercise capacity. However, because elevated LV end-diastolic pressures would result in increased pulmonary artery pressure during rest and exercise, right ventricular ejection fraction may have a closer relationship than LV function with exercise performance in these patients. For example, in 41 men with a variety of causes of chronic LV failure, maximum Vo2 during upright cycle exercise did not correlate with systemic arterial mean pressure, cardiac index, or systemic vascular resistance, but maximum Vo2 did significantly correlate with mean pulmonary artery pressure (r= —0.49) and pulmonary capillary wedge pressure (r= —0.54) at rest, as well as exercise wedge pressure (r= —0.43) and cardiac index (r = 0.72). ampicillin antibiotic

Baker et al measured right ventricular ejection fraction and LV ejection fraction at rest by radionuclide angiography in 25 patients with severe cardiomyopathy (mean maximum Vo2, 13 ± 4 ml/min/kg). Resting LV ejection fraction had a poor correlation with maximum Vo2 (r = 0.08), but right ventricular ejection fraction had a much stronger relationship (r = 0.70, p<0.001).

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Tags: cardiopulmonary exercise testing, heart failure, lung disease, organ systems