Gastrointestinal herpes simplex virus (HSV) infection is predominantly a disease of the esophagus in immunodefi-cient patients. Patients are usually asymptomatic but may experience odynophagia, retrosternal chest pain or fever. Reported cases of disseminated HSV infection in immunocompetent patients are commonly complications of pregnancy . However, rare anecdotal case reports describe HSV viremia, proctocolitis and hemorrhagic cystitis in patients with diabetes mellitus.
The standard gastrointestinal pathology literature describes HSV infection as a localized phenomenon confined to the epithelial tissue circumscribing ulcers. However, few studies describe typical findings of disseminated HSV and its tro-pism within the gastrointestinal tract. Your drugs could cost you less – Buy Symbicort Online to start the treatment soon.
We report a case of disseminated HSV infection of the lung that also complicated ischemic adhesive band disease of the ileum. This patient was predisposed to disseminated HSV infection due to several autoimmune illnesses: type I diabetes, hypothyroidism and celiac disease. HSV cytopathic effect was identified histologically in the ileum mucosal ulcer bed and serosal cellular exudates. Immunohistochemistry (IHC), in situ hybridization (ISH) and conventional and real-time polymerase chain reaction (PCR) confirmed a HSV type II infection.