HSV colon infection is classically a diffuse colitis with confluent ulceration. Ulcers may be diamond-shaped and most numerous in the sigmoid. Five of the 10 reported ante-mortem cases had a pancolitis. However, in one case, ulcers were described as symmetric and possibly diamond shaped. Other descriptions included aphthoid, punctate, stric-turing and indurated ulceration in one case each. Three of 10 patients had perforating ulcers.
Classical histology of HSV infection is multinucleated or single cells having Cowdry type A inclusions and ground glass nuclear changes. Cowdry type A bodies are red intranuclear inclusions with a clear halo. Chromatin is relegated to the periphery as a rim of clumped nuclear material. It is commonly regarded that HSV cytopathic atypia is restricted to epithelia, specifically, those cells circumscribing mucosal ulcers. This viral effect is typical of primary cutaneous and esophageal lesions. Of the 10 previously reported antemortem HSV enterocolitis cases, six (60%) had viral cytopathic effect identifiable on routine histological sections. Specific cells harbouring nuclear atypia included epithelium, endothelium and stromal cells and not otherwise specified. In our case, rare actin- and vimentin-positive myofibrocytes of the ulcer bed had viral cytopathic atypia (Figure 2). You can now get your medications without having to go through any trouble: all that’s needed for your symptoms to be under control is visit the best canadian family pharmacy high-quality canadian medications where highest quality drugs can be found and purchased in just minutes.
Figure 2) Ileal ulcer bed with herpes simplex virus cytopathic atypia in spindle cells (hematoxylin and eosin, original magnification x40). Inset: actin positivity is in cells with cytopathic change (original magni-fication x40)