Nonhuman Primate Models of Menopause (Part 11)

Menopause (Part 11)Metabolic Characteristics of Aging Male and Female Monkeys

This discussion of the metabolic characteristics of aging in male and female monkeys is based on presentations by Dr Joseph Kemnitz (Wisconsin Regional Primate Research Center) and Dr. K.D. Carey (Southwest Foundation for Biomedical Research). canadian neighbor pharmacy online

Rhesus monkey. Longitudinal and cross-sectional measurements were made using primarily indoor-housed rhesus monkeys. Body weight was reasonably stable from 10 to 20 yr of age, with males weighing more than females. Rhesus monkeys older than 25 yr tended to lose weight, primarily from loss of skeletal muscle. Females had greater body fat relative to body weight. Visceral fat deposition increased after menopause but appeared to be related more to age than to menopausal status. Estrogen inhibited food intake in females in a dose-dependent manner; progesterone attenuated the effects of estrogen when the two were administered together. Energy expenditure tended to be lower in the oldest group of females (age, 28-37 yr).

Approximately 50% of rhesus monkeys older than 20 yr had abnormal glucose tolerance relative to young adults. Approximately half these monkeys exhibited hyperinsulin-emia associated with increased adiposity, whereas the other half showed reduced insulin secretion in response to glucose challenges. Overall, females had better glucose tolerance and insulin secretion after glucose challenge than males. Dehydroepiandrosterone (DHEA) declined gradually with age, and supplementation with DHEA lowered cholesterol in middle-aged rhesus monkeys.