Nonhuman Primate Models of Menopause (Part 16)
Bone Changes Caused by Aging and Menopause
This discussion of bone changes caused by aging and menopause is based on presentations by Dr. Mark Lane (Gerontology Research Center, NIA) and Dr. Thomas Clarkson (Wake Forest University School of Medicine). canadian health & care mall
Three issues of interest for bone studies in middle-aged and older animals are age-related bone loss before menopause, bone loss following natural menopause or ovariectomy, and protection from postmenopausal bone loss by estrogen. Bone loss during aging, particularly in premenopausal monkeys, is not well characterized. Major concerns with early studies that reported loss of bone mass with age in rhesus monkeys are the insufficient numbers of older animals studied; the failure to distinguish pre-, peri-, and postmenopausal animals; and the varied methodologies used to assess bone loss and the skeletal sites examined. A recent review article provides an overview of the use of NHPs to study postmenopausal osteoporosis; results summarized from many studies show that the bone response to many interventional hormones and drugs in baboons, cynomolgus monkeys, or rhesus monkeys agrees well with currently available knowledge regarding the actions of these compounds in women.