Nonhuman Primate Models of Menopause (Part 2)

Whether a true animal model of human menopause exists will be clear only after extensive comparative studies. Nonprimate species show substantial differences in reproductive and reproductive aging processes compared with humans, but some of these species, when ovariecto-mized, may provide appropriate models for postmenopausal health problems. Nonhuman primates (NHPs) hold great promise, because some species appear to undergo a process very similar to that which women experience across menopause. However, some important differences, such as substantially shorter postmenopausal life span and differences in the timing of hormonal changes during the menopausal transition, appear to exist. Until sufficient data are obtained, we cannot know whether these differences are genetically determined, species-related differences or whether they result from differences in the environment and/or nutrition of NHPs, nor do we know if these differences compromise the NHP as a model of human menopause. whitening gel

The purpose of this workshop, the latest in a series on animal models of menopause sponsored by the National Institute on Aging (NIA), was to review what is known about the female reproductive aging process in various species of monkeys, including hormone profiles during the menopausal transition, the occurrence of hot flashes, the extent of age-related and menopause-associated changes in hormone levels on metabolism, bone loss, and impaired cardiovascular and cognitive function. With this information, we will be able to evaluate which species of NHP are most likely to shed light on the mechanisms and repercussions of human menopause and to strategically encourage and fund further research that will lead to increased quality of life for postmenopausal women.

Category: Menopause

Tags: aging, neuroendocrinology, ovary, pituitary hormones, steroid hormones