Nonhuman Primate Models of Menopause (Part 20)

The NHP Models of Menopause Workshop was convened to review the current status of knowledge regarding the suitability of the NHP as a valid model of the human menopausal process, including the etiology of postmenopausal health problems and conditions. To what extent do parallelisms exist in the NHP and human female reproductive aging process that lead to the termination of menstrual cycles and to associated declining health and increased risk of multiple diseases? Research findings related to female reproductive aging in several NHP species that were reviewed during this workshop show important similarities and differences with the human menopausal process. However, most importantly, insufficient data exist in many areas regarding the biology of the aging female NHP to allow a critical evaluation of whether these species can provide insights into the human menopause. whitening gel

Apparent Similarities Between NHP and Human Menopause/Aging

Similarities in the female reproductive aging process between NHPs and humans that were presented and discussed at the workshop include 1) general parallelisms in urinary hormone profiles (estrogen, progestin, inhibin, and FSH) across the transition from regular through irregular to terminated cycles in NHPs; 2) progression from regular to irregular cycles in rhesus monkeys, baboons, and chimpanzees, and then to termination of menstrual cycles with at least several years of life remaining in rhesus monkeys and baboons; and 3) fertility in baboons and chimpanzees, which declines substantively in older cycling females.

Category: Menopause

Tags: aging, neuroendocrinology, ovary, pituitary hormones, steroid hormones