Nonhuman Primate Models of Menopause (Part 5)

Menopause (Part 5)

Baboon. Virtually no information is available in the published literature regarding the menopausal process in baboons. In the baboon, reproductive- and menopause-related research is facilitated by the ability to readily discern menstrual cycle status via the skin color and physical changes of the perineum rather than by the need to rely on blood or urinary hormonal measurements. An unpublished pilot study provided data showing that in middle-aged (^15 yr) female baboons with irregular cycles, as defined by the criteria of Chen et al., when averaging short and long irregular cycles over the perimenopausal period, no change was observed in average length of cycle (34.4 days), nor was a difference observed in serum andro-stenedione, total or free testosterone, insulin-like growth factor (IGF)-I, or IGF binding protein-I. canadian neighbor pharmacy online

As in women, baboons with irregular cycles had a shorter follicular phase and were more frequently anovulatory. Relative to premenopause, FSH and LH were elevated in irregularly cycling animals; plasma progesterone, estrone, estradiol, and inhib-in A were lower during the luteal phase; and inhibin B was lower in the follicular phase.

Category: Menopause

Tags: aging, neuroendocrinology, ovary, pituitary hormones, steroid hormones