Nonhuman Primate Models of Menopause (Part 7)

Menopause (Part 7)

Only the conception rate showed profound age-related differences (20% at 15-25 yr of age and <4% at >35 yr of age). A single P. paniscus , aged more than 40 yr (precise age was unknown, because the animal was captured in the wild when already postmature), was observed to be postmenopausal based on terminated menstrual cycles, elevated gonadotropins, and a response to GnRH challenge similar to that of a postmenopausal woman. Thus, the intact chimpanzee appears to be poorly suited as a model of human menopause, not only because of continued cycling until very late in life but also because of the very limited numbers of older females available for research. canadian family pharmacy com

We are not aware of any studies regarding the consequences of ovariectomy, with or without estrogen replacement, in the middle-aged female chimpanzee in terms of bone density, cardiovascular function, and other physiologic systems associated with menopausal health problems.

Neuroendocrine System Changes Across Menopause

This discussion of aging of the reproductive neuroendocrine system is based on presentations by Dr. M. Susan Smith (Oregon Regional Primate Research Center) and Dr Naomi Rance (University of Arizona).