Prognostic Value off Bronchoalveolar Lavage Lymphocyte Count in Recently Diagnosed Pulmonary Sarcoidosis (4)
Study Population and Follow-up
One hundred nineteen subjects with newly diagnosed sarcoidosis were seen at the clinic during the study period. We excluded 12 subjects who had a follow-up of less than six months, as well as nine subjects who had a BAL fluid recovery of less than 35 percent. This report is based on the remaining 98 subjects. During their follow-up, the patients were reevaluated at three- to six-month intervals. The reevaluations included a questionnaire, physical examination, pulmonary function tests, and a lung roentgenogram. The decision to treat (start prednisone therapy) was based on the following criteria: (1) impairment of organs other than the lung; (2) TLC and FVC less than 85 percent of the predicted values; (3) hypoxemia; and (4) persistent symptoms. ampicillin antibiotic
The proportions of treated subjects during follow-up were compared within categories: histologic confirmation of diagnosis, chest x-ray stage, and the lymphocyte count observed at the time of diagnosis (<30 percent or ^30 percent). Statistical differences were assessed by x tests. Age-adjusted comparison of proportions were made by logistic regression. Means of the pulmonary function measures at the end of follow-up were compared for the two groups determined by the BAL lymphocyte count. In patients who were treated, only the pretreatment pulmonary function values were used for analysis.