Reduction of Eosinophilic Inflammation in the Airways: PEF

Reduction of Eosinophilic Inflammation in the Airways: PEFEvening PEF increased significantly with monte-lukast treatment from 438.1 ± 102.5 L/min to 455.4 ± 100.6 L/min (p < 0.005) at 2 weeks and to 464.3 ± 99.0 L/min (p < 0.0005) at 4 weeks, resulting in mean increases of 17.3 ± 20.8 L/min and 26.2 ± 21.2 L/min, respectively. Canadian neighborhood pharmacy read more During the placebo period, PEF changed from 442.1 ± 102.2 L/min at baseline to 441.4 ± 96.1 L/min (NS vs baseline) at 2 weeks, and to 444.3 ± 105.6 L/min (NS vs baseline) at 4 weeks, resulting in mean changes of — 0.7 ± 21.9 L/min and 2.3 ± 30.7 L/min, respectively. There was a statistically significant difference in evening PEF between the montelukast and placebo periods at the end of each period (p < 0.005; Fig 4).
Correlation Between the Decrease in Sputum Eosinophils and the Increase in PEF
The relationship between the decrease in sputum eosinophils and the increase in PEF was investigated in 18 patients in whom both sputum eosinophils and PEF could be monitored. Increases in either morning or evening PEF were not significantly correlated with the decrease in sputum eosinophils, suggesting that the bronchodilatory effects of 4 weeks of treatment with montelukast were not dependent solely on the improvement in airway eosinophilia (Fig 5 and data not shown).
Airway Responsiveness to Histamine
In the montelukast treatment period, PC20 increased from 277.6 ± 861.3 μg/mL at baseline to 305.4 ± 1762.1 μg/mL at 4 weeks (NS vs baseline), resulting in a geometric mean change of 1.1 ± 1.6-fold. In the placebo period, PC20 increased from a baseline value of 263.5 ± 1412.3 μg/mL to 333.7 ± 1690.8 μg/mL (NS vs baseline) at 4 weeks, resulting in a mean change of 1.3 ± 3.1-fold. There was no statistically significant difference between the two periods in the degree of change in this parameter.
Fig5
Figure 5. The relationship between the decrease in sputum eosinophils (percentage) and the increase in morning PEF (liters per minute).

anosiahuman.com