Serum Concentration of Soluble lnterleukin-2 Receptor as a Sensitive Parameter of Disease Activity in Sarcoidosis (2)

The serum level of soluble IL-2R was also shown to be elevated in sarcoidosis, presumably reflecting the activated T-lymphocytes in this disease. We measured serum concentrations of soluble IL-2R to estimate its clinical usefulness in monitoring sarcoidosis. buy prednisone
Materials and Methods fhtient Population
Seventy patients with sarcoidosis were enrolled in this study (Table 1); 29 were males and 41 females with a mean age of 43.9 ± 15.1 years. At the time of diagnosis, all of the patients had typical clinical features of sarcoidosis and the diagnosis was made pathologically or clinically, or both. Serum samples were collected at Tokyo University Hospital between 1980 and 1989 and stored at — 20°C until measurement. Patients with sarcoidosis were divided clinically into three groups: (1) active untreated sarcoidosis, (2) dormant sarcoidosis, and (3) treated sarcoidosis. The active untreated sarcoidosis group was comprised of patients in whom typical signs of sarcoidosis were shown by clinical examinations or chest x-ray film studies and who were not on corticosteroid therapy when serum samples were collected. The dormant sarcoidosis group included patients who once had the disease and showed no active signs of sarcoidosis for more than four weeks before serum samples were obtained. The treated sarcoidosis group was comprised of patients who were receiving corticosteroid therapy for more than four weeks before serum samples were collected. No significant differences in terms of sex, age, smoking history and duration of storage of serum samples were noted among these groups.

Table 1—Study Population

Type of Sarcoidosis
ActiveUntreated Dormant Treated
Cases 34 30 12
Male 15 12 4
Female 19 18 8
Age (yr) 44 ±16 42 ±14 47 ±17
I 23
11 10
111 1