Serum Concentration of Soluble lnterleukin-2 Receptor as a Sensitive Parameter of Disease Activity in Sarcoidosis (5)
Serum Concentrations of Soluble IL-2R in Active, Dormant and Corticosteroid-Treated Sarcoidosis
Serum concentrations of soluble IL-2R were compared among the three groups described previously. The mean value of soluble IL-2R concentrations in serum samples from 34 patients with active untreated sarcoidosis was 1,143 U/ml and that for 30 patients with dormant sarcoidosis was 353 U/ml, and the difference was highly significant (p<0.001; Fig 1), while the normal range was 80 to 300 U/ml in 97 healthy control subjects. The mean value for patients with treated sarcoidosis was 380 U/ml and the difference between treated and untreated patients with active disease also was significant (p<0.001).
Correlation between Serum Concentration of Soluble IL-2R and Serum Angiotensin-Converting Enzyme Levels
Figure 2A shows the relationship between serum concentrations of soluble IL-2R and serum ACE levels in active untreated sarcoidosis, showing a positive correlation (r=0.76). Serum ACE levels from six of 34 patients were within normal limits. On the other hand, values of serum-soluble IL-2R were above the normal level in all patients with active untreated sarcoidosis. The values of both parameters were low in most of the patients with dormant sarcoidosis (Fig 2 B\ but in one patient both of the two parameters remained significantly high after chest x-ray film and ophthalmologic examinations showed resolution of abnormalities. buy asthma inhalers
Figure 1. Serum concentrations of soluble IL-2R in active, dormant and corticosteroid-treated sarcoidosis. The longitudinal bars indicate the standard deviations and the short horizontal bars, the mean values (p<0.001). Shaded area indicates the normal range.
Figure 2. The relationship between concentrations of soluble IL-2R and ACE levels in serum samples of 34 patients with active untreated sarcoidosis (A) and 30 patients with dormant stage disease (B). The correlation coefficient for patients with active untreated disease was 0.76. Shaded area indicates the normal range.