Serum Concentration of Soluble lnterleukin-2 Receptor as a Sensitive Parameter of Disease Activity in Sarcoidosis (9)
Elevated levels of both serum IL-2R and ACE activity of one of our patients with dormant sarcoidosis described previously might be due to some granulomatous lesions that were not manifested by clinical examinations or chest x-ray film studies. Extensive investigations including gallium 67 or BAL analysis seem to be needed for the follow-up in these patients.
Considering that the amount of soluble IL-2R from activated B-cells and monocytes is much smaller than that from activated T-cells in vitro,23 the major source of soluble IL-2R in serum seems to be activated T-cells. If the source of soluble IL-2R in sarcoidosis is activated T-lymphocytes at sites of disease, comparison of serum IL-2R level and parameters in the BAL fluid including BAL fluid IL-2R level also will be important. There was no obvious association between the level of serum concentration of soluble IL-2R and the percentage of lymphocyte or CD4+/CD8+ ratio in our preliminary study. Lawrence et al found a significant increase in the soluble IL-2R level in the concentrated lavage fluid in two thirds of their patients with sarcoidosis. Although measuring soluble IL-2R level in the BAL fluid is not as clinically useful as that in serum samples because of the low level of soluble IL-2R in the BAL fluid and the overlap with data between patients with sarcoidosis and the normal group, investigations in this field seem to be important to clarify the relative roles of the lung in the increased level of serum soluble IL-2R in sarcoidosis. buy ortho tri-cyclen
We concluded that the serum concentration of soluble IL-2R is a sensitive parameter reflecting the disease activity in sarcoidosis. Further studies on the precise mechanism of this subject are needed.