Subclinical Cardiac Dysfunction in Sarcoidosis (10)

Radionuclide Equilibrium Angiography
Twenty-eight patients with sarcoidosis and 18 normal control subjects were studied with RNA (Table 2). There were no significant differences in age, FEVi, and vital capacity between the 28 patients and 18 controls. Resting LVEF was significantly lower in the patients with sarcoidosis compared with controls (53.1 ± 4.2 percent vs 63.1 ± 3.3 percent, respectively, p<0.001). Ten patients with sarcoidosis had LVEF less than 50 percent; of these, five had stage 1, three had stage 2, and two had stage 3 sarcoidosis by chest roentgenogram. Five had normal pulmonary (unction and five had some functional abnormalities. flovent inhaler
The relationship between abnormal HR responses during progressive exercise testing and resting LVEF is shown in Figure 1. Increased HR responses during submaximal exercise were present in 7 of 18 patients with normal LVEF, 1 of 5 patients with LVEF between 40 percent and 50 percent, and 3 of 5 patients with LVEF less than 40 percent. There was no significant relationship (r = 0.18) between resting LVEF and maximum Vo2. There were no significant relationships between the severity of impairment of FVC and either SHR (r=0.18) or LVEF (r = 0.21). Similarly, there were no significant relationships between roentgenographic stage and either SHR (r = 0.11) or resting LVEF (r = 0.12).


Figure 1. The slope of the heart rate response (SHR) during submaximal exercise plotted against left ventricular ejection fraction (LVEF). Individual values are shown. Note that four patients with low LVEF and eight with normal LVEF have increased SHR. The dashed lines indicate LVEF of 50 percent (vertical dashed line) and SHR of 120 percent predicted (horizontal dashed line).