Subclinical Cardiac Dysfunction in Sarcoidosis (12)

Cardiac abnormalities were frequently present at rest and during exercise in the subjects with sarcoidosis. Twenty percent had abnormal resting ECGs showing sinus tachycardia, sinus bradycardia, or normal sinus rhythm with right bundle branch block. Furthermore, continuous ambulatory ECG monitoring showed that the patients with sarcoidosis had significantly higher HRs during normal daily activities than did normal subjects. Circulatory abnormalities were even more apparent during exercise testing. In total, 17 of 35 patients had rapid HRs at rest and/or with exercise, and seven had HR responses to exercise that were significantly lower than the normal subjects (<75 percent of predicted). buy ventolin inhalers

Although the mean SHR response to exercise was not different between patients and controls, 14 of 35 patients showed increased SHR and all of them had AT less than 40 percent predicted Vo2 max, a value considered to represent circulatory impairment, and all except one had Vo2 max below 2 SDs of the normal values. Of the 21 patients with normal or low SHR, 60 percent had lower Vo2max than controls and 33 percent had AT lower than 40 percent predicted Vo2max. These findings indicate that abnormally fast HR responses with exercise are somehow related to the poor exercise performance found in patients with sarcoidosis.