Subclinical Cardiac Dysfunction in Sarcoidosis (16)

However, in contrast with the sarcoid patients, the AT in detrained subjects is generally found to be above 40 percent of maximum predicted Vo2. The control subjects in our study were purposely chosen to be sedentary (ie, not participating in regular exercise programs), and some detraining was expected. However, the AT and SHR were different from those of patients with sarcoidosis. Furthermore, poor fitness has been shown to raise resting LVEF in normal subjects,2^ probably as a result of decreased end-diastolic volume. Ejection fractions were found to be normal or reduced in the sarcoid patients (53.1 ±12.0 percent pred), and were lower than in the untrained controls (63.7± 10.4 percent, p<0.01). Of interest, maximum Vo2 and HR responses to exercise did not change in subjects 16 and 28 on retesting after regular intensive participation in aerobic training. buy cheap antibiotics
Suboptimal effort alone could account for reduced maximum Vo2 during exercise testing. However, both groups in the present study were actively and equally encouraged during the exercise to reach a maximum and achieved greater than 85 percent of predicted maximum HR, indicating satisfactory effort.

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