Furthermore, in contrast with the results seen in the sarcoid population, the SHR during exercise would be expected to be normal if poor effort accounted for their low maximum Vo2. Another potentially confounding variable in the interpretation of our results is the possible effect of corticosteroid medications on cardiovascular and peripheral muscle function. However, no differences were found in HR responses, (maximum Vo2, ventilatory responses, or LVEF) between patients who had and who had not received corticosteroids before or during the study. antibiotic levaquin
The higher percent ideal body weight in the sarcoid group compared with the control group could confound interpretation of our results, because obesity is associated with poor fitness. However, poor fitness related to obesity cannot satisfactorily explain the abnormalities in LVEF, AT, or HR found in our patients. In conclusion, cardiac abnormalities are commonly found in patients with sarcoidosis when stressed by exercise and are manifested by chronotropic and/or inotropic abnormalities. These findings suggest that cardiac involvement may be more common in patients with sarcoidosis than clinically suspected, and this may account for the exertional symptoms and limitation seen in these patients.