Subclinical Cardiac Dysfunction in Sarcoidosis (2)

Subjects and Methods
Subject Selection
Thirty-eight sequential patients were referred to our Respiratory Division with a diagnosis of pulmonary sarcoidosis during the 18-month period of the study. Three patients were excluded from the study because of the presence of one or more of the following exclusion criteria: presence of lung disease other than sarcoidosis, the presence of known intrinsic heart disease, systemic hypertension, anemia, diabetes mellitus, pregnancy, or medication use other than corticosteroids. Thirty-five patients agreed to participate in the study. There were 20 men and 15 women. All patients had clinical presentations and chest roentgenograms consistent with the diagnosis of sarcoidosis. Thirty-three of 35 patients had undergone biopsy procedures for clinical indications independent of the study; microscopically, noncaseating granulomata were found in all 33 patients. Two patients did not undergo biopsy for diagnosis. Thirty-four untrained sedentary patients did not exercise regularly, and only one patient (case 17 in Table 1) was exercising regularly. buy ventolin inhalers
Twenty-eight untrained sedentary asymptomatic normal subjects, including 13 men and 15 women, served as controls for the study. None of the control subjects participated in regular exercise. The study protocol was approved by the Royal Victoria Hospital Ethics Committee and all subjects gave informed consent.

Table 1—Subjects Clinical Characteristics and Roentgenographtc Staging

Normal Subjects Sarcoidosis
No. of subjects 28 35
Mean age, yr 32.2 ±6.3 37.3±9.8t
% ideal weight 96.7±11.0 113.8 ±20.3$
Symptomatic§ 27 (77%)
Roentgenographic staging
1 13 (37%)
2 14 (40%)
3 8 (23%)
Corticosteroid therapy
None 19 (54%)
Present 12 (34%)
Past 4 (12%)

Category: Cardiac Dysfunction

Tags: arterial oxygen, sarcoidosis, tachycardia