Subclinical Cardiac Dysfunction in Sarcoidosis (3)
All 35 patients with sarcoidosis had posterior-anterior and lateral chest roentgenograms. Roentgenographic stage was defined as (1) bilateral hilar adenopathy alone, (2) bilateral hilar adenopathy plus parenchymal infiltrates, and (3) parenchymal infiltrates alone without hilar adenopathy.
Pulmonary Function Testing (PFT)
Patients and normal controls underwent spirometric measurements performed with a calibrated spirometer (Eagle, W.E. Collins, Inc., Braintree, MA). Patients with sarcoidosis also underwent resting single-breath carbon monoxide diffusing capacity (Medical Graphics Corporation 1070 System, Minneapolis, MN) and static lung volume determinations by body plethysmograph (P.K. Morgan, Ltd., U.K.). Results are reported as percent predicted.® Spirometric and static lung volume measurements less than 80 percent of predicted and diffusing capacity measurements less than 70 percent of predicted were considered abnormal. buy yasmin online
Resting Electrocardiograms (ECGs) and Continuous Ambulatory ECG Monitoring
All 35 patients with sarcoidosis had resting 12-lead ECGs. To determine if abnormalities in heart rate (HR) were present in these patients during normal daily activities, 24-hour Holter ECG recordings (minimum 18 hours) were performed in 17 randomly chosen (eight male, nine female) patients with sarcoidosis, and 12 (seven male, five female) normal control subjects. A dual channel recorder 4-24/2 (Oxford Medilog AM) with two bipolar monitoring leads was used.