Subclinical Cardiac Dysfunction in Sarcoidosis (6)
Radionuclide Equilibrium Angiography
To investigate whether abnormal exercise HR responses in patients without evident cardiac sarcoidosis were related to impaired ventricular contractility, left ventricular ejection fraction (LVEF) was measured by gated equilibrium radionuclide angiography (RNA) performed at rest. This technique was used to evaluate ventricular performance in 28 patients and 18 normal controls. The method used for gated RNA is described in another study from our laboratory. ampicillin antibiotic
Mean values for clinical characteristics and data from PFTs, 24-hour Holter monitoring, progressive exercise testing, and gated RNA were compared between the group with sarcoidosis and normal controls using Students t test for independent means. Values for p less than 0.05 were considered statistically significant. Values are reported as mean ± standard deviation (SD). Correlation coefficients from linear regression analysis between certain parameters were also performed. Values for p less than 0.05 were considered statistically significant.
Subjects Characteristics, Roentgenographic Stage, and Corticosteroid Treatment Status
The clinical characteristics of patients with sarcoidosis and normal controls are shown in Table 1. The range of time from diagnosis of sarcoidosis in the 35 patients was 1 to 240 months. Mean age and percentage of ideal body weight were significantly greater in the group with sarcoidosis compared with controls.