Subclinical Cardiac Dysfunction in Sarcoidosis (9)
Although the slope of the minute ventilation response to exercise (Table 2) was significantly greater in the group with sarcoidosis than normal controls (p<0.001), none of the patients reached predicted maximum voluntary ventilation (MW). Maximum Ve was not significantly different between the groups (Table 2). Three patients exceeded 80 percent of Ve/MW (Table 2). Arterial oxygen desaturation occurred with exercise in only one patient. buy birth control online
Maximum HR was greater than 85 percent predicted in both groups, indicating satisfactory efforts during testing, and it was not significantly different between groups. However, rapid HRs were common at rest and during exercise in the patients with sarcoidosis (Table 2). Resting HR at the beginning of exercise testing was significantly higher in the patients with sarcoidosis than normal control subjects (p<0.01), and was greater than 100 beats per minute in eight patients. The SHR response to exercise was not significantly different between groups (Table 2), but 14 patients had increased SHR, ie, higher than 120 percent predicted, and six patients had decreased SHR, ie, lower than 75 percent predicted. Six of 14 patients with increased SHR had resting tachycardia. Mean 6-hour HR from continuous ambulatory ECG recordings from the 18- to 0-hour period and 0- to 6-hour period correlated with resting HR prior to exercise testing (r = 0.52, p<0.05 and r = 0.60, p<0.01, respectively). The AT (Table 2), an index of the adequacy of oxygen delivery during exercise, was significantly lower in the group with sarcoidosis than normal controls (p<0.001). All the 14 patients with increased SHR had AT less than 40 percent Vo2 max predicted while low AT was present in 33 percent of patients with normal SHR and only 3 percent of controls.